Stress-induced analgesia in μ-opioid receptor knockout mice reveals normal function of the δ-opioid receptor system

Christopher J. Labuda, Ichiro Sora, George R. Uhl, Perry N. Fuchs

Research output: Contribution to journalArticle

Abstract

Stress-induced analgesia (SIA) was examined in wildtype and μ-opioid receptor knockout mice. We used thermal paw withdrawal (TPW) latency following a continuous 3-min swim in 20°C water, and found a significant increase in TPW latency in both wild-type and knockout mice. Pre-treatment prior to the swim with naltrindole, a selective δ-opioid receptor antagonist, blocked the increase in TPW latency in knockout mice. These results demonstrate an intact δ-receptor-mediated function of a physiologically-released endogenous agonist in the μ-opioid receptor knockout mouse. The present findings are in contrast with previous reports that analgesia induced by exogenous delta agonists is reduced in the knockout mice. Theme: Neurotransmitters, modulators, transporters, and receptors. Topic: Opioid receptors. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalBrain Research
Volume869
Issue number1-2
DOIs
StatePublished - Jun 30 2000

Keywords

  • Antinociception
  • Morphine
  • Naltrindole
  • Opioid receptor
  • Stress-induced analgesia
  • Transgenic mouse

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Stress-induced analgesia in μ-opioid receptor knockout mice reveals normal function of the δ-opioid receptor system'. Together they form a unique fingerprint.

  • Cite this