Streptococcus pneumoniae: Resistance update and treatment options

Research output: Chapter in Book/Report/Conference proceedingChapter


Streptococcus pneumoniae is a major worldwide bacterial pathogen responsible for a variety of infections including pneumonia, bacteremia, otitis media, meningitis, sinusitis, and other infections. It is the most common pathogen causing bacterial community-acquired pneumonia (CAP) (1). Pneumococcal pneumonia has always been responsible for significant morbidity and mortality. In the pre-antibiotic era, it carried a 25% to 35% case fatality rate, which increased to 80% if bacteremia was present (2). Following the introduction of penicillin, mortality rates were reduced to below 10% (3). Sixty years later, mortality rates still remain around 12% for all hospitalized patients (1) and up to 25% for those with bacteremia (1,4). The continued significant mortality of pneumococcal disease despite the advances in antimicrobial therapy and intensive care management over the past half-century underscores the innate pathogenicity of this organism.

Original languageEnglish (US)
Title of host publicationAntimicrobial Resistance
Subtitle of host publicationProblem Pathogens and Clinical Countermeasures
PublisherCRC Press
Number of pages14
ISBN (Electronic)9781420017236
ISBN (Print)9780824729417
StatePublished - Jan 1 2007

ASJC Scopus subject areas

  • Medicine(all)


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