Strength training increases regional bone mineral density and bone remodeling in middle-aged and older men

A. Menkes, S. Mazel, R. A. Redmond, K. Koffler, C. R. Libanati, C. M. Gundberg, T. M. Zizic, J. M. Hagberg, R. E. Pratley, B. F. Hurley

Abstract

To determine the effects of strength training (ST) on bone mineral density (BMD) and bone remodeling, 18 previously inactive untrained males [mean age 59 ± 2 (SE) yr] were studied before and after 16 wk of either ST (n = 11) or no exercise (inactive controls; n = 7). Total, spinal (L2-L4), and femoral neck BMD were measured in nine training and seven control subjects before and after the experimental period. Serum concentrations of osteocalcin, skeletal alkaline phosphatase isoenzyme, and tartrate-resistant acid phosphatase were measured before, during, and after the experimental program in all subjects. Training increased muscular strength by an average of 45 ± 3% (P <0.001) on a three-repetition maximum test and by 32 ± 4% (P <0.001) on an isokinetic test of the knee extensors performed at 60°/s. BMD increased in the femoral neck by 3.8 ± 1.0% (0.900 ± 0.05 vs. 0.933 ± 0.05 g/cm2, P <0.05) and in the lumbar spine by 2.0 ± 0.9% (1.180 ± 0.06 vs. 1.203 ± 0.06 g/cm2, P <0.05). However, changes in lumbar spine BMD were not significantly different from those in the control group. There was no significant change in total body BMD. Osteocalcin increased by 19 ± 6% after 12 wk of training (P <0.05) and remained significantly elevated after 16 wk of training (P <0.05). There was a 26 ± 11% increase in skeletal alkaline phosphatase isoenzyme levels (P <0.05) after 16 wk of training. There were no significant differences in tartrate-resistant acid phosphatase levels. There were no significant changes in muscular strength, BMD, or any of the serum markers in the control group. These findings confirm that 16 wk of ST in middle-aged and older men results in increased regional BMD. These increases may be mediated by an increase in bone formation.

Original languageEnglish (US)
Pages (from-to)2478-2484
Number of pages7
JournalJournal of Applied Physiology
Volume74
Issue number5
StatePublished - 1993
Externally publishedYes

Fingerprint

Resistance Training
Bone Remodeling
Bone Density
Bone and Bones
Femur Neck
Osteocalcin
Acid Phosphatase
Isoenzymes
Alkaline Phosphatase
Spine
Osteogenesis
Knee
Biological Markers
Exercise
Serum

Keywords

  • bone formation
  • bone resorption

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Menkes, A., Mazel, S., Redmond, R. A., Koffler, K., Libanati, C. R., Gundberg, C. M., ... Hurley, B. F. (1993). Strength training increases regional bone mineral density and bone remodeling in middle-aged and older men. Journal of Applied Physiology, 74(5), 2478-2484.

Strength training increases regional bone mineral density and bone remodeling in middle-aged and older men. / Menkes, A.; Mazel, S.; Redmond, R. A.; Koffler, K.; Libanati, C. R.; Gundberg, C. M.; Zizic, T. M.; Hagberg, J. M.; Pratley, R. E.; Hurley, B. F.

In: Journal of Applied Physiology, Vol. 74, No. 5, 1993, p. 2478-2484.

Research output: Contribution to journalArticle

Menkes, A, Mazel, S, Redmond, RA, Koffler, K, Libanati, CR, Gundberg, CM, Zizic, TM, Hagberg, JM, Pratley, RE & Hurley, BF 1993, 'Strength training increases regional bone mineral density and bone remodeling in middle-aged and older men' Journal of Applied Physiology, vol 74, no. 5, pp. 2478-2484.
Menkes A, Mazel S, Redmond RA, Koffler K, Libanati CR, Gundberg CM et al. Strength training increases regional bone mineral density and bone remodeling in middle-aged and older men. Journal of Applied Physiology. 1993;74(5):2478-2484.

Menkes, A.; Mazel, S.; Redmond, R. A.; Koffler, K.; Libanati, C. R.; Gundberg, C. M.; Zizic, T. M.; Hagberg, J. M.; Pratley, R. E.; Hurley, B. F. / Strength training increases regional bone mineral density and bone remodeling in middle-aged and older men.

In: Journal of Applied Physiology, Vol. 74, No. 5, 1993, p. 2478-2484.

Research output: Contribution to journalArticle

@article{220f4ce47dc249dcbabbe22c14d466c9,
title = "Strength training increases regional bone mineral density and bone remodeling in middle-aged and older men",
keywords = "bone formation, bone resorption",
author = "A. Menkes and S. Mazel and Redmond, {R. A.} and K. Koffler and Libanati, {C. R.} and Gundberg, {C. M.} and Zizic, {T. M.} and Hagberg, {J. M.} and Pratley, {R. E.} and Hurley, {B. F.}",
year = "1993",
volume = "74",
pages = "2478--2484",
journal = "Journal of Applied Physiology",
issn = "0161-7567",
publisher = "American Physiological Society",
number = "5",

}

TY - JOUR

T1 - Strength training increases regional bone mineral density and bone remodeling in middle-aged and older men

AU - Menkes,A.

AU - Mazel,S.

AU - Redmond,R. A.

AU - Koffler,K.

AU - Libanati,C. R.

AU - Gundberg,C. M.

AU - Zizic,T. M.

AU - Hagberg,J. M.

AU - Pratley,R. E.

AU - Hurley,B. F.

PY - 1993

Y1 - 1993

KW - bone formation

KW - bone resorption

UR - http://www.scopus.com/inward/record.url?scp=0027196173&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027196173&partnerID=8YFLogxK

M3 - Article

VL - 74

SP - 2478

EP - 2484

JO - Journal of Applied Physiology

T2 - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 0161-7567

IS - 5

ER -