Abstract
To determine the effects of strength training (ST) on bone mineral density (BMD) and bone remodeling, 18 previously inactive untrained males [mean age 59 ± 2 (SE) yr] were studied before and after 16 wk of either ST (n = 11) or no exercise (inactive controls; n = 7). Total, spinal (L2-L4), and femoral neck BMD were measured in nine training and seven control subjects before and after the experimental period. Serum concentrations of osteocalcin, skeletal alkaline phosphatase isoenzyme, and tartrate-resistant acid phosphatase were measured before, during, and after the experimental program in all subjects. Training increased muscular strength by an average of 45 ± 3% (P <0.001) on a three-repetition maximum test and by 32 ± 4% (P <0.001) on an isokinetic test of the knee extensors performed at 60°/s. BMD increased in the femoral neck by 3.8 ± 1.0% (0.900 ± 0.05 vs. 0.933 ± 0.05 g/cm2, P <0.05) and in the lumbar spine by 2.0 ± 0.9% (1.180 ± 0.06 vs. 1.203 ± 0.06 g/cm2, P <0.05). However, changes in lumbar spine BMD were not significantly different from those in the control group. There was no significant change in total body BMD. Osteocalcin increased by 19 ± 6% after 12 wk of training (P <0.05) and remained significantly elevated after 16 wk of training (P <0.05). There was a 26 ± 11% increase in skeletal alkaline phosphatase isoenzyme levels (P <0.05) after 16 wk of training. There were no significant differences in tartrate-resistant acid phosphatase levels. There were no significant changes in muscular strength, BMD, or any of the serum markers in the control group. These findings confirm that 16 wk of ST in middle-aged and older men results in increased regional BMD. These increases may be mediated by an increase in bone formation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2478-2484 |
| Number of pages | 7 |
| Journal | Journal of Applied Physiology |
| Volume | 74 |
| Issue number | 5 |
| State | Published - 1993 |
| Externally published | Yes |
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Keywords
- bone formation
- bone resorption
ASJC Scopus subject areas
- Physiology
- Endocrinology
- Orthopedics and Sports Medicine
- Physical Therapy, Sports Therapy and Rehabilitation
Cite this
Strength training increases regional bone mineral density and bone remodeling in middle-aged and older men. / Menkes, A.; Mazel, S.; Redmond, R. A.; Koffler, K.; Libanati, C. R.; Gundberg, C. M.; Zizic, Thomas M.; Hagberg, J. M.; Pratley, R. E.; Hurley, B. F.
In: Journal of Applied Physiology, Vol. 74, No. 5, 1993, p. 2478-2484.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Strength training increases regional bone mineral density and bone remodeling in middle-aged and older men
AU - Menkes, A.
AU - Mazel, S.
AU - Redmond, R. A.
AU - Koffler, K.
AU - Libanati, C. R.
AU - Gundberg, C. M.
AU - Zizic, Thomas M.
AU - Hagberg, J. M.
AU - Pratley, R. E.
AU - Hurley, B. F.
PY - 1993
Y1 - 1993
N2 - To determine the effects of strength training (ST) on bone mineral density (BMD) and bone remodeling, 18 previously inactive untrained males [mean age 59 ± 2 (SE) yr] were studied before and after 16 wk of either ST (n = 11) or no exercise (inactive controls; n = 7). Total, spinal (L2-L4), and femoral neck BMD were measured in nine training and seven control subjects before and after the experimental period. Serum concentrations of osteocalcin, skeletal alkaline phosphatase isoenzyme, and tartrate-resistant acid phosphatase were measured before, during, and after the experimental program in all subjects. Training increased muscular strength by an average of 45 ± 3% (P <0.001) on a three-repetition maximum test and by 32 ± 4% (P <0.001) on an isokinetic test of the knee extensors performed at 60°/s. BMD increased in the femoral neck by 3.8 ± 1.0% (0.900 ± 0.05 vs. 0.933 ± 0.05 g/cm2, P <0.05) and in the lumbar spine by 2.0 ± 0.9% (1.180 ± 0.06 vs. 1.203 ± 0.06 g/cm2, P <0.05). However, changes in lumbar spine BMD were not significantly different from those in the control group. There was no significant change in total body BMD. Osteocalcin increased by 19 ± 6% after 12 wk of training (P <0.05) and remained significantly elevated after 16 wk of training (P <0.05). There was a 26 ± 11% increase in skeletal alkaline phosphatase isoenzyme levels (P <0.05) after 16 wk of training. There were no significant differences in tartrate-resistant acid phosphatase levels. There were no significant changes in muscular strength, BMD, or any of the serum markers in the control group. These findings confirm that 16 wk of ST in middle-aged and older men results in increased regional BMD. These increases may be mediated by an increase in bone formation.
AB - To determine the effects of strength training (ST) on bone mineral density (BMD) and bone remodeling, 18 previously inactive untrained males [mean age 59 ± 2 (SE) yr] were studied before and after 16 wk of either ST (n = 11) or no exercise (inactive controls; n = 7). Total, spinal (L2-L4), and femoral neck BMD were measured in nine training and seven control subjects before and after the experimental period. Serum concentrations of osteocalcin, skeletal alkaline phosphatase isoenzyme, and tartrate-resistant acid phosphatase were measured before, during, and after the experimental program in all subjects. Training increased muscular strength by an average of 45 ± 3% (P <0.001) on a three-repetition maximum test and by 32 ± 4% (P <0.001) on an isokinetic test of the knee extensors performed at 60°/s. BMD increased in the femoral neck by 3.8 ± 1.0% (0.900 ± 0.05 vs. 0.933 ± 0.05 g/cm2, P <0.05) and in the lumbar spine by 2.0 ± 0.9% (1.180 ± 0.06 vs. 1.203 ± 0.06 g/cm2, P <0.05). However, changes in lumbar spine BMD were not significantly different from those in the control group. There was no significant change in total body BMD. Osteocalcin increased by 19 ± 6% after 12 wk of training (P <0.05) and remained significantly elevated after 16 wk of training (P <0.05). There was a 26 ± 11% increase in skeletal alkaline phosphatase isoenzyme levels (P <0.05) after 16 wk of training. There were no significant differences in tartrate-resistant acid phosphatase levels. There were no significant changes in muscular strength, BMD, or any of the serum markers in the control group. These findings confirm that 16 wk of ST in middle-aged and older men results in increased regional BMD. These increases may be mediated by an increase in bone formation.
KW - bone formation
KW - bone resorption
UR - http://www.scopus.com/inward/record.url?scp=0027196173&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027196173&partnerID=8YFLogxK
M3 - Article
C2 - 8335581
AN - SCOPUS:0027196173
VL - 74
SP - 2478
EP - 2484
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
SN - 0161-7567
IS - 5
ER -