Straub tail reaction in mice treated with σ1 receptor antagonist in combination with methamphetamine

Junichi Kitanaka, Nobue Kitanaka, F. Scott Hall, George R. Uhl, Koh Ichi Tanaka, Nobuyoshi Nishiyama, Motohiko Takemura

Research output: Contribution to journalArticlepeer-review

Abstract

Straub tail reaction (STR) was observed in male ddY mice after simultaneous administration with BMY 14802 (a non-specific σ receptor antagonist) and methamphetamine (METH). The intensity and duration of STR depended on the dose of BMY 14802. The tail reaction was inhibited completely by ()-SKF 10,047 (a putative σ1 receptor agonist) and partially by PB 28 (a putative σ2 receptor agonist). The STR was mimicked in mice treated with BD 1047 (a putative σ1 receptor antagonist), but not SM-21, a putative σ2 receptor antagonist, in combination with METH. STR evoked with BD 1047 plus METH was inhibited by ()-SKF 10,047. STR induced by BMY 14802 and METH was abolished by naloxone (a relatively non-selective opioid receptor antagonist) or U-50,488H (a selective κ-agonist), suggesting that the STR may be mediated by activation of opioid receptor system.

Original languageEnglish (US)
Pages (from-to)40-46
Number of pages7
JournalBrain Research
Volume1482
DOIs
StatePublished - Oct 30 2012
Externally publishedYes

Keywords

  • Methamphetamine
  • Opioid receptor system
  • Sigma ligand
  • Straub tail reaction

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Developmental Biology
  • Molecular Biology

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