@article{25062ee053ef46ffa6784e1fcb264776,
title = "Strategies to Promote Long-Distance Optic Nerve Regeneration",
abstract = "Mammalian retinal ganglion cells (RGCs) in the central nervous system (CNS) often die after optic nerve injury and surviving RGCs fail to regenerate their axons, eventually resulting in irreversible vision loss. Manipulation of a diverse group of genes can significantly boost optic nerve regeneration of mature RGCs by reactivating developmental-like growth programs or suppressing growth inhibitory pathways. By injury of the vision pathway near their brain targets, a few studies have shown that regenerated RGC axons could form functional synapses with targeted neurons but exhibited poor neural conduction or partial functional recovery. Therefore, the functional restoration of eye-to-brain pathways remains a greatly challenging issue. Here, we review recent advances in long-distance optic nerve regeneration and the subsequent reconnecting to central targets. By summarizing our current strategies for promoting functional recovery, we hope to provide potential insights into future exploration in vision reformation after neural injuries.",
keywords = "axon regeneration, functional recovery, glaucoma, optic nerve, retinal ganglion cells",
author = "Yang, {Shu Guang} and Li, {Chang Ping} and Peng, {Xue Qi} and Teng, {Zhao Qian} and Liu, {Chang Mei} and Zhou, {Feng Quan}",
note = "Funding Information: For this work, F-QZ was supported by grants from NIH (National Eye Institute; National Institute of Neurological Disorders and Stroke; R01NS085176, R01EY027347, R01EY030883), the Craig H. Neilsen Foundation (259450), and the Birght Focus Foundation (G2017037). C-ML was supported by grants from the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA16010302), the National Key Research and Development Program of China Project (2016YFA0101402), and the National Science Foundation of China (91753140). S-GY was supported by the grant from the National Science Foundation of China (81370051). Funding Information: Funding. For this work, F-QZ was supported by grants from NIH (National Eye Institute; National Institute of Neurological Disorders and Stroke; R01NS085176, R01EY027347, R01EY030883), the Craig H. Neilsen Foundation (259450), and the Birght Focus Foundation (G2017037). C-ML was supported by grants from the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA16010302), the National Key Research and Development Program of China Project (2016YFA0101402), and the National Science Foundation of China (91753140). S-GY was supported by the grant from the National Science Foundation of China (81370051). Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2020 Yang, Li, Peng, Teng, Liu and Zhou.",
year = "2020",
month = may,
day = "14",
doi = "10.3389/fncel.2020.00119",
language = "English (US)",
volume = "14",
journal = "Frontiers in Cellular Neuroscience",
issn = "1662-5102",
publisher = "Frontiers Research Foundation",
}