TY - JOUR
T1 - Strategies to Maximize Patient Participation in Clinical Trials
AU - Rubin, Eric H.
AU - Scroggins, Mary J.
AU - Goldberg, Kirsten B.
AU - Beaver, Julia A.
PY - 2017
Y1 - 2017
N2 - Despite considerable interest and success in oncology drug development, the minority of patients with cancer diagnoses enroll in clinical trials. Multiple obstacles account for this low enrollment rate. An improvement in patient participation in clinical trials could increase patient access to novel and potentially promising agents, provide faster trial results, and, with implementation of rational eligibility criteria, allow for a better understanding of the drug's safety and efficacy in a heterogeneous population. We present barriers and potential solutions to maximize patient participation, including a review of the ASCO and Friends of Cancer Research (FoCR) Modernizing Eligibility Criteria Project, U.S. Food and Drug Administration (FDA) regulatory considerations, an industry perspective, and a patient perspective.
AB - Despite considerable interest and success in oncology drug development, the minority of patients with cancer diagnoses enroll in clinical trials. Multiple obstacles account for this low enrollment rate. An improvement in patient participation in clinical trials could increase patient access to novel and potentially promising agents, provide faster trial results, and, with implementation of rational eligibility criteria, allow for a better understanding of the drug's safety and efficacy in a heterogeneous population. We present barriers and potential solutions to maximize patient participation, including a review of the ASCO and Friends of Cancer Research (FoCR) Modernizing Eligibility Criteria Project, U.S. Food and Drug Administration (FDA) regulatory considerations, an industry perspective, and a patient perspective.
UR - http://www.scopus.com/inward/record.url?scp=85051533407&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85051533407&partnerID=8YFLogxK
U2 - 10.14694/EDBK_179803
DO - 10.14694/EDBK_179803
M3 - Article
C2 - 28561724
AN - SCOPUS:85051533407
SN - 1548-8756
VL - 37
SP - 216
EP - 221
JO - American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting
JF - American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting
ER -