Strategies to improve DNA vaccine potency: HPV-associated cervical cancer as a model system

Chien Fu Hung, Barbara Ma, Yijie Xu, T. C. Wu

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cancer immunotherapy, particularly antigen-specific immunotherapy, has become a potentially promising approach for control of cancer due to its ability to kill tumor cells without harming normal cells. Among different forms of antigen-specific immunotherapy, DNA vaccines are an attractive approach because of their safety, simplicity and ease of mass production. However, they suffer from low immunogenicity due to their inability to amplify and spread in vivo and therefore require innovative strategies to enhance the immune response stimulated by DNA vaccines. Strategies to improve DNA vaccine efficacy should focus on dendritic cells (DCs) because they are the most potent activators of an antigen-specific T cell response, which is crucial in the control of tumors. Increased understanding of DC biology has created opportunities to improve DNA vaccine potency through the applications of strategies that modify the function of DCs. In this review, we use human papillomavirus (HPV)-associated cervical cancer as a model system to illustrate the various strategies that improve DNA vaccine potency. Specifically, we will discuss the various strategies to improve targeting of DNA to DCs, antigen processing and presentation by DCs and DC interactions with T cells in this book chapter.

Original languageEnglish (US)
Title of host publicationGene Vaccines
PublisherSpringer-Verlag Wien
Pages37-65
Number of pages29
Volume9783709104392
ISBN (Electronic)9783709104392
ISBN (Print)3709104386, 9783709104385
DOIs
StatePublished - Mar 1 2012

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

Fingerprint Dive into the research topics of 'Strategies to improve DNA vaccine potency: HPV-associated cervical cancer as a model system'. Together they form a unique fingerprint.

  • Cite this