Strategies to determine the biological function of micrornas

Jan Krützfeldt, Matthew Poy, Markus Stoffel

Research output: Contribution to journalArticle

Abstract

MicroRNAs (miRNAs) are regulators of gene expression that control many biological processes in development, differentiation, growth and metabolism. Their expression levels, small size, abundance of repetitive copies in the genome and mode of action pose unique challenges in studies elucidating the function of miRNAs. New technologies for identification, expression profiling and target gene validation, as well as manipulation of miRNA expression in vivo, will facilitate the study of their contribution to biological processes and disease. Such information will be crucial to exploit the emerging knowledge of miRNAs for the development of new human therapeutic applications.

Original languageEnglish (US)
Pages (from-to)S14
JournalNature Genetics
Volume38
Issue number6S
DOIs
StatePublished - Jan 1 2006
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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