Abstract
MicroRNAs (miRNAs) are regulators of gene expression that control many biological processes in development, differentiation, growth and metabolism. Their expression levels, small size, abundance of repetitive copies in the genome and mode of action pose unique challenges in studies elucidating the function of miRNAs. New technologies for identification, expression profiling and target gene validation, as well as manipulation of miRNA expression in vivo, will facilitate the study of their contribution to biological processes and disease. Such information will be crucial to exploit the emerging knowledge of miRNAs for the development of new human therapeutic applications.
| Original language | English (US) |
|---|---|
| Pages (from-to) | S14 |
| Journal | Nature Genetics |
| Volume | 38 |
| Issue number | 6S |
| DOIs | |
| State | Published - Jan 1 2006 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Genetics
Cite this
Strategies to determine the biological function of micrornas. / Krützfeldt, Jan; Poy, Matthew; Stoffel, Markus.
In: Nature Genetics, Vol. 38, No. 6S, 01.01.2006, p. S14.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Strategies to determine the biological function of micrornas
AU - Krützfeldt, Jan
AU - Poy, Matthew
AU - Stoffel, Markus
PY - 2006/1/1
Y1 - 2006/1/1
N2 - MicroRNAs (miRNAs) are regulators of gene expression that control many biological processes in development, differentiation, growth and metabolism. Their expression levels, small size, abundance of repetitive copies in the genome and mode of action pose unique challenges in studies elucidating the function of miRNAs. New technologies for identification, expression profiling and target gene validation, as well as manipulation of miRNA expression in vivo, will facilitate the study of their contribution to biological processes and disease. Such information will be crucial to exploit the emerging knowledge of miRNAs for the development of new human therapeutic applications.
AB - MicroRNAs (miRNAs) are regulators of gene expression that control many biological processes in development, differentiation, growth and metabolism. Their expression levels, small size, abundance of repetitive copies in the genome and mode of action pose unique challenges in studies elucidating the function of miRNAs. New technologies for identification, expression profiling and target gene validation, as well as manipulation of miRNA expression in vivo, will facilitate the study of their contribution to biological processes and disease. Such information will be crucial to exploit the emerging knowledge of miRNAs for the development of new human therapeutic applications.
UR - http://www.scopus.com/inward/record.url?scp=84984765629&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84984765629&partnerID=8YFLogxK
U2 - 10.1038/ng1799
DO - 10.1038/ng1799
M3 - Article
C2 - 16736018
AN - SCOPUS:84984765629
VL - 38
SP - S14
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 6S
ER -