Strategies for the Care of Adults Hospitalized for Active Ulcerative Colitis

Suresh Pola, Derek Patel, Sonia Ramamoorthy, Elisabeth McLemore, Marianne Fahmy, Jesus Rivera-Nieves, John T. Chang, Elisabeth Evans, Michael Docherty, Mark Talamini, William J. Sandborn

Research output: Contribution to journalReview article

Abstract

Ulcerative colitis is a chronic inflammatory disease of the colon; as many as 25% of patients with this disease require hospitalization. The goals of hospitalization are to assess disease severity, exclude infection, administer rapidly acting and highly effective medication regimens, and determine response. During hospitalization, patients should be given venous thromboembolism prophylaxis and monitored for the development of toxic megacolon. Patients who do not respond to intravenous corticosteroids should be considered for rescue therapy with infliximab or cyclosporine. Patients who are refractory to medical therapies or who develop toxic megacolon should be evaluated promptly for colectomy. Patients who do respond to medical therapies should be discharged on an appropriate maintenance regimen when they meet discharge criteria. We review practical evidence-based management principles and propose a day-by-day algorithm for managing patients hospitalized for ulcerative colitis.

Original languageEnglish (US)
Pages (from-to)1315-1325.e4
JournalClinical Gastroenterology and Hepatology
Volume10
Issue number12
DOIs
StatePublished - Dec 2012

Keywords

  • CMV
  • CT
  • Colectomy
  • IBD
  • Inflammatory Bowel Disease
  • Inpatient Management
  • PCR
  • TNF
  • TPMT
  • UC
  • Ulcerative Colitis

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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  • Cite this

    Pola, S., Patel, D., Ramamoorthy, S., McLemore, E., Fahmy, M., Rivera-Nieves, J., Chang, J. T., Evans, E., Docherty, M., Talamini, M., & Sandborn, W. J. (2012). Strategies for the Care of Adults Hospitalized for Active Ulcerative Colitis. Clinical Gastroenterology and Hepatology, 10(12), 1315-1325.e4. https://doi.org/10.1016/j.cgh.2012.07.006