Strategies for local gene therapy of corneal allograft rejection

Pho Nguyen, Samuel C. Yiu

Research output: Contribution to journalArticlepeer-review

Abstract

Penetrating keratoplasty is the most common type of tissue transplant in humans. Irreversible immune rejection leads to loss of vision and graft failure. This complex immune response further predisposes future corneal transplants to rejection and failure. A diverse armamentarium of surgical and pharmacologic tools is available to improve graft survival. In this review, we will discuss the various gene therapeutic strategies aimed at potentiating the anterior chamber-associated immune deviation to extend graft survival.

Original languageEnglish (US)
Pages (from-to)11-25
Number of pages15
JournalMiddle East African Journal of Ophthalmology
Volume20
Issue number1
DOIs
StatePublished - Jan 2013

Keywords

  • Adenovirus
  • Corneal Transplant
  • Dendrimer
  • Gene Therapy
  • Immune Privilege
  • Neovascularization
  • Plasmid
  • Rejection

ASJC Scopus subject areas

  • Ophthalmology

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