Strategies for chemoprevention of liver cancer

Thomas W. Kensler, Patricia A. Egner, Jin Bing Wang, Yuan Rong Zhu, Bao Chu Zhang, Geng Sun Qian, Shuang Yuan Kuang, Stephen J. Gange, Lisa P. Jacobson, Alvaro Muñoz, John D. Groopman

Research output: Contribution to journalArticlepeer-review

Abstract

Liver cancer is one of the most common cancers worldwide. Infection with hepatitis B virus and exposure to aflatoxins in the diet act synergistically to amplify risk. From a public health perspective, hepatitis virus vaccination programs and efforts to both reduce aflatoxin exposures and to attenuate the toxicological consequences of unavoidable exposures should have major impacts on the incidence of this disease. Experimentally, aflatoxin-induced hepatocarcinogenesis can be inhibited by over a score of different chemopreventive agents with multiple mechanisms of action. One agent, oltipraz, is a potent inducer of phase 2 enzymes involved in the detoxication of carcinogens including aflatoxin. A second agent, chlorophyllin, impedes the bioavailability of carcinogens by forming molecular complexes and enhances their elimination in the fecal stream. This review highlights the findings of recent randomized clinical trials with oltipraz and chlorophyllin conducted in individuals exposed to dietary aflatoxins and at high risk for development of liver cancer. Both chemopreventive agents modulated levels of aflatoxin biomarkers in the study participants in manners consonant with protection.

Original languageEnglish (US)
Pages (from-to)S58-S64
JournalEuropean Journal of Cancer Prevention
Volume11
Issue numberSUPPL. 2
StatePublished - Aug 2002

Keywords

  • Aflatoxin
  • Biomarkers
  • Chemoprevention
  • Chlorophyllin
  • Clinical trials
  • Liver cancer
  • Oltipraz
  • Phase 2 enzymes

ASJC Scopus subject areas

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

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