Strategies and techniques to enhance the in situ endothelialization of small-diameter biodegradable polymeric vascular grafts

Anthony J. Melchiorri, Narutoshi Hibino, John P. Fisher

Research output: Contribution to journalReview articlepeer-review

Abstract

Due to the lack of success in small-diameter (<6 mm) prosthetic vascular grafts, a variety of strategies have evolved utilizing a tissue-engineering approach. Much of this work has focused on enhancing the endothelialization of these grafts. A healthy, confluent endothelial layer provides dynamic control over homeo-stasis, influencing and preventing thrombosis and smooth muscle cell proliferation that can lead to intimal hyperplasia. Strategies to improve endothelialization of biodegradable polymeric grafts have encompassed both chemical and physical modifications to graft surfaces, many focusing on the recruitment of endothelial and endothelial progenitor cells. This review aims to provide a compilation of current and developing strategies that utilize in situ endothelialization to improve vascular graft outcomes, providing a context for the future directions of vascular tissue-engineering strategies that do not require preprocedural cell seeding.

Original languageEnglish (US)
Pages (from-to)292-307
Number of pages16
JournalTissue Engineering - Part B: Reviews
Volume19
Issue number4
DOIs
StatePublished - Aug 1 2013
Externally publishedYes

ASJC Scopus subject areas

  • Bioengineering
  • Medicine(all)
  • Biochemistry
  • Biomaterials
  • Biomedical Engineering

Fingerprint Dive into the research topics of 'Strategies and techniques to enhance the in situ endothelialization of small-diameter biodegradable polymeric vascular grafts'. Together they form a unique fingerprint.

Cite this