Strain-specific induction of experimental autoimmune prostatitis (EAP) in mice

Christopher M. Jackson, Dallas B. Flies, Claudio A. Mosse, Anil Parwani, Edward L. Hipkiss, Charles G. Drake

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND Prostatitis, a clinical syndrome characterized by pelvic pain and inflammation, is common in adult males. Although several induced and spontaneous murine models of prostatitis have been explored, the role of genetic background on induction has not been well-defined. METHODS Using a standard methodology for the induction of experimental autoimmune prostatitis (EAP), we investigated both acute and chronic inflammation on several murine genetic backgrounds. RESULTS In our colony, nonobese diabetic (NOD) mice evinced spontaneous prostatitis that was not augmented by immunization with rat prostate extract (RPE). In contrast, the standard laboratory strain Balb/c developed chronic inflammation in response to RPE immunization. Development of EAP in other strains was variable. CONCLUSIONS These data suggest that Balb/c mice injected with RPE may provide a useful model for chronic prostatic inflammation. Prostate 73: 651-656, 2013. © 2012 Wiley Periodicals, Inc.

Original languageEnglish (US)
Pages (from-to)651-656
Number of pages6
JournalProstate
Volume73
Issue number6
DOIs
StatePublished - May 2013

Keywords

  • autoimmunity
  • inflammation
  • prostate
  • prostatitis

ASJC Scopus subject areas

  • Urology
  • Oncology

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