Strain-encoded (SENC) magnetic resonance imaging to evaluate regional heterogeneity of myocardial strain in healthy volunteers

Comparison with conventional tagging

Mirja Neizel, Dirk Lossnitzer, Grigorios Korosoglou, Tim Schäufele, Antje Lewien, Henning Steen, Hugo A. Katus, Nael Fakhry Osman, Evangelos Giannitsis

Research output: Contribution to journalArticle

Abstract

Purpose: To evaluate the ability of strain-encoded (SENC) magnetic resonance imaging (MRI) for regional systolic and diastolic strain analysis of the myocardium in healthy volunteers. Materials and Methods: Circumferential and longitudinal peak systolic strain values of 75 healthy volunteers (35 women and 40 men, mean age 44 ± 12 years) were measured using SENC at 1.5T. MR tagging was used as the reference standard for measuring regional function. Diastolic function was assessed in the 10 youngest (24 ± 8 years) and 10 oldest (62 ± 5 years) subjects. Results: Peak strain values assessed with SENC were comparable to those obtained by MR tagging, showing narrow limits of agreement (limits of agreement -5.6% to 8.1%). Regional heterogeneity was observed between different segments of the left ventricle (LV) by both techniques (P <0.001). Longitudinal strain obtained by SENC was also heterogenous (P <0.001). Interestingly, no age- or gender-specific differences in peak systolic strain were observed, whereas the peak rate of relaxation of circumferential strain rate was decreased in the older group. Conclusion SENC is a reliable tool for accurate and objective quantification of regional myocardial systolic as well as diastolic function. In agreement with tagged MRI, SENC detected slightly heterogeneous myocardial strain within LV segments.

Original languageEnglish (US)
Pages (from-to)99-105
Number of pages7
JournalJournal of Magnetic Resonance Imaging
Volume29
Issue number1
DOIs
StatePublished - Jan 2009

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Heart Ventricles
Healthy Volunteers
Magnetic Resonance Imaging
Myocardium

Keywords

  • Diastolic function
  • Magnetic resonance imaging
  • Myocardial strain
  • Normal ventricle
  • Strain-encoded imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Strain-encoded (SENC) magnetic resonance imaging to evaluate regional heterogeneity of myocardial strain in healthy volunteers : Comparison with conventional tagging. / Neizel, Mirja; Lossnitzer, Dirk; Korosoglou, Grigorios; Schäufele, Tim; Lewien, Antje; Steen, Henning; Katus, Hugo A.; Osman, Nael Fakhry; Giannitsis, Evangelos.

In: Journal of Magnetic Resonance Imaging, Vol. 29, No. 1, 01.2009, p. 99-105.

Research output: Contribution to journalArticle

Neizel, Mirja ; Lossnitzer, Dirk ; Korosoglou, Grigorios ; Schäufele, Tim ; Lewien, Antje ; Steen, Henning ; Katus, Hugo A. ; Osman, Nael Fakhry ; Giannitsis, Evangelos. / Strain-encoded (SENC) magnetic resonance imaging to evaluate regional heterogeneity of myocardial strain in healthy volunteers : Comparison with conventional tagging. In: Journal of Magnetic Resonance Imaging. 2009 ; Vol. 29, No. 1. pp. 99-105.
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abstract = "Purpose: To evaluate the ability of strain-encoded (SENC) magnetic resonance imaging (MRI) for regional systolic and diastolic strain analysis of the myocardium in healthy volunteers. Materials and Methods: Circumferential and longitudinal peak systolic strain values of 75 healthy volunteers (35 women and 40 men, mean age 44 ± 12 years) were measured using SENC at 1.5T. MR tagging was used as the reference standard for measuring regional function. Diastolic function was assessed in the 10 youngest (24 ± 8 years) and 10 oldest (62 ± 5 years) subjects. Results: Peak strain values assessed with SENC were comparable to those obtained by MR tagging, showing narrow limits of agreement (limits of agreement -5.6{\%} to 8.1{\%}). Regional heterogeneity was observed between different segments of the left ventricle (LV) by both techniques (P <0.001). Longitudinal strain obtained by SENC was also heterogenous (P <0.001). Interestingly, no age- or gender-specific differences in peak systolic strain were observed, whereas the peak rate of relaxation of circumferential strain rate was decreased in the older group. Conclusion SENC is a reliable tool for accurate and objective quantification of regional myocardial systolic as well as diastolic function. In agreement with tagged MRI, SENC detected slightly heterogeneous myocardial strain within LV segments.",
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AB - Purpose: To evaluate the ability of strain-encoded (SENC) magnetic resonance imaging (MRI) for regional systolic and diastolic strain analysis of the myocardium in healthy volunteers. Materials and Methods: Circumferential and longitudinal peak systolic strain values of 75 healthy volunteers (35 women and 40 men, mean age 44 ± 12 years) were measured using SENC at 1.5T. MR tagging was used as the reference standard for measuring regional function. Diastolic function was assessed in the 10 youngest (24 ± 8 years) and 10 oldest (62 ± 5 years) subjects. Results: Peak strain values assessed with SENC were comparable to those obtained by MR tagging, showing narrow limits of agreement (limits of agreement -5.6% to 8.1%). Regional heterogeneity was observed between different segments of the left ventricle (LV) by both techniques (P <0.001). Longitudinal strain obtained by SENC was also heterogenous (P <0.001). Interestingly, no age- or gender-specific differences in peak systolic strain were observed, whereas the peak rate of relaxation of circumferential strain rate was decreased in the older group. Conclusion SENC is a reliable tool for accurate and objective quantification of regional myocardial systolic as well as diastolic function. In agreement with tagged MRI, SENC detected slightly heterogeneous myocardial strain within LV segments.

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