Strain-Encoded Cardiac MR During High-Dose Dobutamine Stress Testing

Comparison to Cine Imaging and to Myocardial Tagging

Grigorios Korosoglou, Simon Futterer, Per M. Humpert, Nina Riedle, Dirk Lossnitzer, Birgit Hoerig, Henning Steen, Evangelos Giannitsis, Nael Fakhry Osman, Hugo A. Katus

Research output: Contribution to journalArticle

Abstract

Purpose: To investigate regional strain response during high-dose dobutamine stress cardiac magnetic resonance imaging (DS-CMR) using myocardial tagging and Strain- Encoded MR (SENC). Materials and Methods: Stress induced ischemia was as- sessed by wall motion analysis, by tagged CMR and by SENC in 65 patients with suspected or known CAD who underwent DS-CMR in a clinical 1.5 Tesla scanner. Coronary angiogra- phy deemed as the standard reference for the presence or absence of CAD (50% diameter stenosis) in all patients. Results: SENC and conventional tagging detected abnor- mal strain response in six and five additional patients, respectively, who were missed by cine images and proved to have CAD by angiography (P 0.05 for SENC versus cine, P 0.06 for tagging versus cine and p NS for SENC versus tagging). On a per-vessel level, wall motion analysis on cine images showed high specificity (95%) but moderate sensitivity (70%) for the detection of CAD. Tagging and SENC yielded significantly higher sensitivity of 81% and 89%, respectively (P 0.05 for tagging and P 0.01 for SENC versus wall motion analysis, and p NS for SENC versus tagging), while specificity was equally high (96% and 94%, respectively, P NS for all). Conclusion: Both the direct color-coded visualization of strain on CMR images and the generation of additional visual markers within the myocardium with tagged CMR represent useful adjuncts for DS-CMR, which may provide incremental value for the detection of CAD in humans.

Original languageEnglish (US)
Pages (from-to)1053-1061
Number of pages9
JournalJournal of Magnetic Resonance Imaging
Volume29
Issue number5
DOIs
StatePublished - May 2009

Fingerprint

Dobutamine
Magnetic Resonance Imaging
Coronary Angiography
Myocardium
Angiography
Pathologic Constriction
Ischemia
Color

Keywords

  • Dobutamine stress
  • Inducible ischemia
  • Myocardial strain response
  • Strain-Encoded MR
  • tagged CMR

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Korosoglou, G., Futterer, S., Humpert, P. M., Riedle, N., Lossnitzer, D., Hoerig, B., ... Katus, H. A. (2009). Strain-Encoded Cardiac MR During High-Dose Dobutamine Stress Testing: Comparison to Cine Imaging and to Myocardial Tagging. Journal of Magnetic Resonance Imaging, 29(5), 1053-1061. https://doi.org/10.1002/jmri.21759

Strain-Encoded Cardiac MR During High-Dose Dobutamine Stress Testing : Comparison to Cine Imaging and to Myocardial Tagging. / Korosoglou, Grigorios; Futterer, Simon; Humpert, Per M.; Riedle, Nina; Lossnitzer, Dirk; Hoerig, Birgit; Steen, Henning; Giannitsis, Evangelos; Osman, Nael Fakhry; Katus, Hugo A.

In: Journal of Magnetic Resonance Imaging, Vol. 29, No. 5, 05.2009, p. 1053-1061.

Research output: Contribution to journalArticle

Korosoglou, G, Futterer, S, Humpert, PM, Riedle, N, Lossnitzer, D, Hoerig, B, Steen, H, Giannitsis, E, Osman, NF & Katus, HA 2009, 'Strain-Encoded Cardiac MR During High-Dose Dobutamine Stress Testing: Comparison to Cine Imaging and to Myocardial Tagging', Journal of Magnetic Resonance Imaging, vol. 29, no. 5, pp. 1053-1061. https://doi.org/10.1002/jmri.21759
Korosoglou, Grigorios ; Futterer, Simon ; Humpert, Per M. ; Riedle, Nina ; Lossnitzer, Dirk ; Hoerig, Birgit ; Steen, Henning ; Giannitsis, Evangelos ; Osman, Nael Fakhry ; Katus, Hugo A. / Strain-Encoded Cardiac MR During High-Dose Dobutamine Stress Testing : Comparison to Cine Imaging and to Myocardial Tagging. In: Journal of Magnetic Resonance Imaging. 2009 ; Vol. 29, No. 5. pp. 1053-1061.
@article{593adfe12a2541fd988e9d90c24e3537,
title = "Strain-Encoded Cardiac MR During High-Dose Dobutamine Stress Testing: Comparison to Cine Imaging and to Myocardial Tagging",
abstract = "Purpose: To investigate regional strain response during high-dose dobutamine stress cardiac magnetic resonance imaging (DS-CMR) using myocardial tagging and Strain- Encoded MR (SENC). Materials and Methods: Stress induced ischemia was as- sessed by wall motion analysis, by tagged CMR and by SENC in 65 patients with suspected or known CAD who underwent DS-CMR in a clinical 1.5 Tesla scanner. Coronary angiogra- phy deemed as the standard reference for the presence or absence of CAD (50{\%} diameter stenosis) in all patients. Results: SENC and conventional tagging detected abnor- mal strain response in six and five additional patients, respectively, who were missed by cine images and proved to have CAD by angiography (P 0.05 for SENC versus cine, P 0.06 for tagging versus cine and p NS for SENC versus tagging). On a per-vessel level, wall motion analysis on cine images showed high specificity (95{\%}) but moderate sensitivity (70{\%}) for the detection of CAD. Tagging and SENC yielded significantly higher sensitivity of 81{\%} and 89{\%}, respectively (P 0.05 for tagging and P 0.01 for SENC versus wall motion analysis, and p NS for SENC versus tagging), while specificity was equally high (96{\%} and 94{\%}, respectively, P NS for all). Conclusion: Both the direct color-coded visualization of strain on CMR images and the generation of additional visual markers within the myocardium with tagged CMR represent useful adjuncts for DS-CMR, which may provide incremental value for the detection of CAD in humans.",
keywords = "Dobutamine stress, Inducible ischemia, Myocardial strain response, Strain-Encoded MR, tagged CMR",
author = "Grigorios Korosoglou and Simon Futterer and Humpert, {Per M.} and Nina Riedle and Dirk Lossnitzer and Birgit Hoerig and Henning Steen and Evangelos Giannitsis and Osman, {Nael Fakhry} and Katus, {Hugo A.}",
year = "2009",
month = "5",
doi = "10.1002/jmri.21759",
language = "English (US)",
volume = "29",
pages = "1053--1061",
journal = "Journal of Magnetic Resonance Imaging",
issn = "1053-1807",
publisher = "John Wiley and Sons Inc.",
number = "5",

}

TY - JOUR

T1 - Strain-Encoded Cardiac MR During High-Dose Dobutamine Stress Testing

T2 - Comparison to Cine Imaging and to Myocardial Tagging

AU - Korosoglou, Grigorios

AU - Futterer, Simon

AU - Humpert, Per M.

AU - Riedle, Nina

AU - Lossnitzer, Dirk

AU - Hoerig, Birgit

AU - Steen, Henning

AU - Giannitsis, Evangelos

AU - Osman, Nael Fakhry

AU - Katus, Hugo A.

PY - 2009/5

Y1 - 2009/5

N2 - Purpose: To investigate regional strain response during high-dose dobutamine stress cardiac magnetic resonance imaging (DS-CMR) using myocardial tagging and Strain- Encoded MR (SENC). Materials and Methods: Stress induced ischemia was as- sessed by wall motion analysis, by tagged CMR and by SENC in 65 patients with suspected or known CAD who underwent DS-CMR in a clinical 1.5 Tesla scanner. Coronary angiogra- phy deemed as the standard reference for the presence or absence of CAD (50% diameter stenosis) in all patients. Results: SENC and conventional tagging detected abnor- mal strain response in six and five additional patients, respectively, who were missed by cine images and proved to have CAD by angiography (P 0.05 for SENC versus cine, P 0.06 for tagging versus cine and p NS for SENC versus tagging). On a per-vessel level, wall motion analysis on cine images showed high specificity (95%) but moderate sensitivity (70%) for the detection of CAD. Tagging and SENC yielded significantly higher sensitivity of 81% and 89%, respectively (P 0.05 for tagging and P 0.01 for SENC versus wall motion analysis, and p NS for SENC versus tagging), while specificity was equally high (96% and 94%, respectively, P NS for all). Conclusion: Both the direct color-coded visualization of strain on CMR images and the generation of additional visual markers within the myocardium with tagged CMR represent useful adjuncts for DS-CMR, which may provide incremental value for the detection of CAD in humans.

AB - Purpose: To investigate regional strain response during high-dose dobutamine stress cardiac magnetic resonance imaging (DS-CMR) using myocardial tagging and Strain- Encoded MR (SENC). Materials and Methods: Stress induced ischemia was as- sessed by wall motion analysis, by tagged CMR and by SENC in 65 patients with suspected or known CAD who underwent DS-CMR in a clinical 1.5 Tesla scanner. Coronary angiogra- phy deemed as the standard reference for the presence or absence of CAD (50% diameter stenosis) in all patients. Results: SENC and conventional tagging detected abnor- mal strain response in six and five additional patients, respectively, who were missed by cine images and proved to have CAD by angiography (P 0.05 for SENC versus cine, P 0.06 for tagging versus cine and p NS for SENC versus tagging). On a per-vessel level, wall motion analysis on cine images showed high specificity (95%) but moderate sensitivity (70%) for the detection of CAD. Tagging and SENC yielded significantly higher sensitivity of 81% and 89%, respectively (P 0.05 for tagging and P 0.01 for SENC versus wall motion analysis, and p NS for SENC versus tagging), while specificity was equally high (96% and 94%, respectively, P NS for all). Conclusion: Both the direct color-coded visualization of strain on CMR images and the generation of additional visual markers within the myocardium with tagged CMR represent useful adjuncts for DS-CMR, which may provide incremental value for the detection of CAD in humans.

KW - Dobutamine stress

KW - Inducible ischemia

KW - Myocardial strain response

KW - Strain-Encoded MR

KW - tagged CMR

UR - http://www.scopus.com/inward/record.url?scp=66149132678&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=66149132678&partnerID=8YFLogxK

U2 - 10.1002/jmri.21759

DO - 10.1002/jmri.21759

M3 - Article

VL - 29

SP - 1053

EP - 1061

JO - Journal of Magnetic Resonance Imaging

JF - Journal of Magnetic Resonance Imaging

SN - 1053-1807

IS - 5

ER -