Strain-dependent CNS dissemination in guinea pigs after Mycobacterium tuberculosis aerosol challenge

Nicholas A. Be, Lee G. Klinkenberg, William R. Bishai, Petros C. Karakousis, Sanjay K. Jain

Research output: Contribution to journalArticlepeer-review

Abstract

Clinical reports suggest an association of distinct Mycobacterium tuberculosis strains with CNS disease. We therefore examined CNS dissemination by different laboratory strains (two M. tuberculosis H37Rv, one CDC1551) in a guinea pig aerosol infection model. Although all strains grew exponentially in lungs, with similar bacterial burdens at the time of extrapulmonary dissemination, M. tuberculosis CDC1551 disseminated to the CNS significantly more than the H37Rv strains. No CNS lesions were observed throughout the study, with only a modest cytokine response. These data suggest that M. tuberculosis may have virulence factors that promote CNS dissemination, distinct from those required for pulmonary TB.

Original languageEnglish (US)
Pages (from-to)386-389
Number of pages4
JournalTuberculosis
Volume91
Issue number5
DOIs
StatePublished - Sep 2011

Keywords

  • Central nervous system
  • Dissemination
  • Guinea pig
  • Meningitis
  • Tuberculosis

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Microbiology (medical)
  • Infectious Diseases

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