Strain comparison of systemic N-nitrosohexamethyleneimine carcinogenesis in BALB c, SENCAR and CD-1 mice

Paul Timothy Strickland, William Lijinsky, Barbara Thomas, Robert M. Kovatch

Research output: Contribution to journalArticle

Abstract

SENCAR mice have been selectively bred for hypersusceptibility to 2-stage chemical skin carcinogenesis. In this study the relative susceptibilities of SENCAR, BALB c and CD-1 mice to systemic carcinogenesis by N-nitrosohexamethyleneimine (NHEX) were examined. NHEX was administered twice weekly (1 mg/mouse) in corn oil by gavage for 30 weeks. NHEX caused primarily liver and lung tumors in all 3 strains of mice. Hemangiosarcomas (but not other liver tumors) were more common in CD-1 mice than BALB c or SENCAR mice. Lung tumors (adenomas and adenocarcinomas) and forestomach tumors (squamous carcinomas) were more common in SENCAR mice than BALB c or CD-1 mice. Survival was better in SENCAR mice dosed with NHEX than in the other 2 strains. These results indicate that SENCAR mice are not unusually sensitive to liver carcinogenesis by NHEX, but are relatively sensitive to tumorigenesis in 2 epithelial tissues, lung and forestomach.

Original languageEnglish (US)
Pages (from-to)139-146
Number of pages8
JournalCancer Letters
Volume41
Issue number2
DOIs
StatePublished - Aug 15 1988

Fingerprint

N-nitrosoperhydroazepine
Inbred SENCAR Mouse
Carcinogenesis
Lung
Liver
Neoplasms
Hemangiosarcoma
Corn Oil
Adenoma
Squamous Cell Carcinoma
Adenocarcinoma
Epithelium
Skin

Keywords

  • Mouse strains
  • N-Nitroso compounds
  • Tumor sites

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

Strain comparison of systemic N-nitrosohexamethyleneimine carcinogenesis in BALB c, SENCAR and CD-1 mice. / Strickland, Paul Timothy; Lijinsky, William; Thomas, Barbara; Kovatch, Robert M.

In: Cancer Letters, Vol. 41, No. 2, 15.08.1988, p. 139-146.

Research output: Contribution to journalArticle

Strickland, Paul Timothy ; Lijinsky, William ; Thomas, Barbara ; Kovatch, Robert M. / Strain comparison of systemic N-nitrosohexamethyleneimine carcinogenesis in BALB c, SENCAR and CD-1 mice. In: Cancer Letters. 1988 ; Vol. 41, No. 2. pp. 139-146.
@article{9cc6b4ccd4844250b8f5a5d3239f511a,
title = "Strain comparison of systemic N-nitrosohexamethyleneimine carcinogenesis in BALB c, SENCAR and CD-1 mice",
abstract = "SENCAR mice have been selectively bred for hypersusceptibility to 2-stage chemical skin carcinogenesis. In this study the relative susceptibilities of SENCAR, BALB c and CD-1 mice to systemic carcinogenesis by N-nitrosohexamethyleneimine (NHEX) were examined. NHEX was administered twice weekly (1 mg/mouse) in corn oil by gavage for 30 weeks. NHEX caused primarily liver and lung tumors in all 3 strains of mice. Hemangiosarcomas (but not other liver tumors) were more common in CD-1 mice than BALB c or SENCAR mice. Lung tumors (adenomas and adenocarcinomas) and forestomach tumors (squamous carcinomas) were more common in SENCAR mice than BALB c or CD-1 mice. Survival was better in SENCAR mice dosed with NHEX than in the other 2 strains. These results indicate that SENCAR mice are not unusually sensitive to liver carcinogenesis by NHEX, but are relatively sensitive to tumorigenesis in 2 epithelial tissues, lung and forestomach.",
keywords = "Mouse strains, N-Nitroso compounds, Tumor sites",
author = "Strickland, {Paul Timothy} and William Lijinsky and Barbara Thomas and Kovatch, {Robert M.}",
year = "1988",
month = "8",
day = "15",
doi = "10.1016/0304-3835(88)90110-3",
language = "English (US)",
volume = "41",
pages = "139--146",
journal = "Cancer Letters",
issn = "0304-3835",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Strain comparison of systemic N-nitrosohexamethyleneimine carcinogenesis in BALB c, SENCAR and CD-1 mice

AU - Strickland, Paul Timothy

AU - Lijinsky, William

AU - Thomas, Barbara

AU - Kovatch, Robert M.

PY - 1988/8/15

Y1 - 1988/8/15

N2 - SENCAR mice have been selectively bred for hypersusceptibility to 2-stage chemical skin carcinogenesis. In this study the relative susceptibilities of SENCAR, BALB c and CD-1 mice to systemic carcinogenesis by N-nitrosohexamethyleneimine (NHEX) were examined. NHEX was administered twice weekly (1 mg/mouse) in corn oil by gavage for 30 weeks. NHEX caused primarily liver and lung tumors in all 3 strains of mice. Hemangiosarcomas (but not other liver tumors) were more common in CD-1 mice than BALB c or SENCAR mice. Lung tumors (adenomas and adenocarcinomas) and forestomach tumors (squamous carcinomas) were more common in SENCAR mice than BALB c or CD-1 mice. Survival was better in SENCAR mice dosed with NHEX than in the other 2 strains. These results indicate that SENCAR mice are not unusually sensitive to liver carcinogenesis by NHEX, but are relatively sensitive to tumorigenesis in 2 epithelial tissues, lung and forestomach.

AB - SENCAR mice have been selectively bred for hypersusceptibility to 2-stage chemical skin carcinogenesis. In this study the relative susceptibilities of SENCAR, BALB c and CD-1 mice to systemic carcinogenesis by N-nitrosohexamethyleneimine (NHEX) were examined. NHEX was administered twice weekly (1 mg/mouse) in corn oil by gavage for 30 weeks. NHEX caused primarily liver and lung tumors in all 3 strains of mice. Hemangiosarcomas (but not other liver tumors) were more common in CD-1 mice than BALB c or SENCAR mice. Lung tumors (adenomas and adenocarcinomas) and forestomach tumors (squamous carcinomas) were more common in SENCAR mice than BALB c or CD-1 mice. Survival was better in SENCAR mice dosed with NHEX than in the other 2 strains. These results indicate that SENCAR mice are not unusually sensitive to liver carcinogenesis by NHEX, but are relatively sensitive to tumorigenesis in 2 epithelial tissues, lung and forestomach.

KW - Mouse strains

KW - N-Nitroso compounds

KW - Tumor sites

UR - http://www.scopus.com/inward/record.url?scp=0023719720&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023719720&partnerID=8YFLogxK

U2 - 10.1016/0304-3835(88)90110-3

DO - 10.1016/0304-3835(88)90110-3

M3 - Article

C2 - 3401840

AN - SCOPUS:0023719720

VL - 41

SP - 139

EP - 146

JO - Cancer Letters

JF - Cancer Letters

SN - 0304-3835

IS - 2

ER -