Strain as a novel index of regional pulmonary function from thoracic 4-D CT images: In-vivo validation with tomographic SPECT ventilation and perfusion

Mohammadreza Negahdar, Neal Dunlap, Albert Zacarias, Ali Civelek, Shiao Y. Woo, Amir A. Amini

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Since many diseases or injuries can cause biomechanical or structural property changes that can alter lung function, there is great interest in measuring regional lung function by measurement of regional mechanical changes. To date, the most prevalent approach for assessing regional lung function from 4-D X-ray CT data has been a measure of Jacobian of deformation. However, although the Jacobian describes regional volume changes of the lung during deformation, it lacks any consideration of directional changes of local compressions and expansions during respiration. Herein, we propose the use of strain as a measure of regional lung function from 4-D thoracic CT and we perform correlation of principal strains of calculated deformation by s recently proposed 3-D optical flow technique (MOFID) computed from radiotherapy treatment planning 4-D X-ray CT data sets collected in seven subjects suffering from non-small cell primary lung cancer. In addition to 4-D CT data, both SPECT ventilation (VSPECT), and SPECT perfusion (QSPECT) data were acquired in all subjects. For each subject, we performed voxel-wise statistical correlation of the Jacobian as well as principal strains of deformation (CT-derived pulmonary function images) with both ventilation and perfusion SPECT. For all subjects, the maximum principal strain resulted in a higher correlation with both SPECT ventilation and SPECT perfusion than other indices including the previously established Jacobian metric.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8672
DOIs
StatePublished - 2013
Externally publishedYes
EventMedical Imaging 2013: Biomedical Applications in Molecular, Structural, and Functional Imaging - Lake Buena Vista, FL, United States
Duration: Feb 10 2013Feb 13 2013

Other

OtherMedical Imaging 2013: Biomedical Applications in Molecular, Structural, and Functional Imaging
CountryUnited States
CityLake Buena Vista, FL
Period2/10/132/13/13

Fingerprint

pulmonary functions
ventilation
Single-Photon Emission-Computed Tomography
lungs
Ventilation
Thorax
Perfusion
Lung
X Ray Computed Tomography
X rays
Optical flows
statistical correlation
Radiotherapy
respiration
Structural properties
Non-Small Cell Lung Carcinoma
planning
radiation therapy
Respiration
x rays

Keywords

  • 4-D X-ray CT
  • Image registration
  • Jacobian
  • Lung function
  • Regional ventilation
  • SPECT
  • Strain

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Negahdar, M., Dunlap, N., Zacarias, A., Civelek, A., Woo, S. Y., & Amini, A. A. (2013). Strain as a novel index of regional pulmonary function from thoracic 4-D CT images: In-vivo validation with tomographic SPECT ventilation and perfusion. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 8672). [867213] https://doi.org/10.1117/12.2009734

Strain as a novel index of regional pulmonary function from thoracic 4-D CT images : In-vivo validation with tomographic SPECT ventilation and perfusion. / Negahdar, Mohammadreza; Dunlap, Neal; Zacarias, Albert; Civelek, Ali; Woo, Shiao Y.; Amini, Amir A.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8672 2013. 867213.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Negahdar, M, Dunlap, N, Zacarias, A, Civelek, A, Woo, SY & Amini, AA 2013, Strain as a novel index of regional pulmonary function from thoracic 4-D CT images: In-vivo validation with tomographic SPECT ventilation and perfusion. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 8672, 867213, Medical Imaging 2013: Biomedical Applications in Molecular, Structural, and Functional Imaging, Lake Buena Vista, FL, United States, 2/10/13. https://doi.org/10.1117/12.2009734
Negahdar M, Dunlap N, Zacarias A, Civelek A, Woo SY, Amini AA. Strain as a novel index of regional pulmonary function from thoracic 4-D CT images: In-vivo validation with tomographic SPECT ventilation and perfusion. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8672. 2013. 867213 https://doi.org/10.1117/12.2009734
Negahdar, Mohammadreza ; Dunlap, Neal ; Zacarias, Albert ; Civelek, Ali ; Woo, Shiao Y. ; Amini, Amir A. / Strain as a novel index of regional pulmonary function from thoracic 4-D CT images : In-vivo validation with tomographic SPECT ventilation and perfusion. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8672 2013.
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