Stomach-genetic and epigenetic alterations of preneoplastic and neoplastic lesions

Stefan David, Stephen J. Meltzera

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Gastric cancer is one of the most common neoplasias in the world and remains an important cause of cancer-related mortality. Vast resources have been invested in the study of the molecular events driving the development and progression of gastric tumors. Gastric cancer is known to result from an interaction between host and environmental factors. The present review will discuss the most how genetic and epigenetic changes contribute to gastric carcinogenesis and their potential for developing novel diagnostic and therapeutic tools.

Original languageEnglish (US)
Title of host publicationTranslational pathology of early cancer
PublisherIOS Press
Pages493-507
Number of pages15
ISBN (Print)9781614990239
DOIs
StatePublished - Mar 1 2012

Keywords

  • Deletion
  • Epigenetics
  • Gastric cancer
  • Genetics
  • Methylation
  • Microsatellite Instabilitychromosomal Instability
  • Mutation
  • Oncogene
  • Translocation
  • Tumor Suppressor Gene

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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