Stochastic Modelling of Multiple Random Genetic Mutations Under the Cancer Stem Cell Hypothesis

Cristian Tomasetti

doi:10.1080/08898480.2012.725379

Stochastic Modelling of Multiple Random Genetic Mutations Under the Cancer Stem Cell Hypothesis

Cristian Tomasetti

Research output: Contribution to journal › Article › peer-review

Abstract

The probability distribution for the size of each of the various cancer cell subpopulations created by random genetic mutations is expressed in the case of non-exponential growth of cancer and in the case of a heterogeneous tumor cell population.

Original language	English (US)
Pages (from-to)	200-213
Number of pages	14
Journal	Mathematical Population Studies
Volume	19
Issue number	4
DOIs	https://doi.org/10.1080/08898480.2012.725379
State	Published - Oct 2012
Externally published	Yes

Keywords

branching processes
genetic mutations
stem cells
tumor growth
tumor heterogeneity

ASJC Scopus subject areas

Demography
Geography, Planning and Development
General Agricultural and Biological Sciences

Access to Document

10.1080/08898480.2012.725379

Cite this

@article{40f28453a1f24e358cc8ee2c13cff389,

title = "Stochastic Modelling of Multiple Random Genetic Mutations Under the Cancer Stem Cell Hypothesis",

abstract = "The probability distribution for the size of each of the various cancer cell subpopulations created by random genetic mutations is expressed in the case of non-exponential growth of cancer and in the case of a heterogeneous tumor cell population.",

keywords = "branching processes, genetic mutations, stem cells, tumor growth, tumor heterogeneity",

author = "Cristian Tomasetti",

note = "Funding Information: The author thanks Prof. Giovanni Parmigiani for his support and encouragement. The author{\textquoteright}s work was supported in part by the National Institute of Health under Grant T32 CA009337.",

year = "2012",

month = oct,

doi = "10.1080/08898480.2012.725379",

language = "English (US)",

volume = "19",

pages = "200--213",

journal = "Mathematical Population Studies",

issn = "0889-8480",

publisher = "Taylor and Francis Ltd.",

number = "4",

}

TY - JOUR

T1 - Stochastic Modelling of Multiple Random Genetic Mutations Under the Cancer Stem Cell Hypothesis

AU - Tomasetti, Cristian

N1 - Funding Information: The author thanks Prof. Giovanni Parmigiani for his support and encouragement. The author’s work was supported in part by the National Institute of Health under Grant T32 CA009337.

PY - 2012/10

Y1 - 2012/10

N2 - The probability distribution for the size of each of the various cancer cell subpopulations created by random genetic mutations is expressed in the case of non-exponential growth of cancer and in the case of a heterogeneous tumor cell population.

AB - The probability distribution for the size of each of the various cancer cell subpopulations created by random genetic mutations is expressed in the case of non-exponential growth of cancer and in the case of a heterogeneous tumor cell population.

KW - branching processes

KW - genetic mutations

KW - stem cells

KW - tumor growth

KW - tumor heterogeneity

UR - http://www.scopus.com/inward/record.url?scp=84867202938&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84867202938&partnerID=8YFLogxK

U2 - 10.1080/08898480.2012.725379

DO - 10.1080/08898480.2012.725379

M3 - Article

AN - SCOPUS:84867202938

SN - 0889-8480

VL - 19

SP - 200

EP - 213

JO - Mathematical Population Studies

JF - Mathematical Population Studies

IS - 4

ER -

Stochastic Modelling of Multiple Random Genetic Mutations Under the Cancer Stem Cell Hypothesis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this