STN-Stimulation in Parkinson's disease restores striatal inhibition of thalamocortical projection

Jacob Geday, Karen Østergaard, Erik Johnsen, Albert Gjedde

Research output: Contribution to journalArticle

Abstract

To test the hypothesis that deep brain stimulation of the subthalamic nucleus (STN) restores the inhibitory output to the striatothalamocortical loop in Parkinson's disease, we obtained functional brain images of blood flow in 10 STN-stimulated patients with Parkinson's disease. Patients were Immobile and off antiparkinsonian medication for 12 h. They "were scanned with and without bilateral STN-stimulation with a 4-h interval between the two conditions. The order of DBS stimulation (ON or OFF) was randomized. Stimulation significantly raised regional cerebral blood flow (rCBF) bilaterally in the STN and in the left nucleus lentiformis. Conversely, flow declined in the left supplementary motor area (BA 6), ventrolateral nucleus of the left thalamus, and right cerebellum. Activation of the basal ganglia and deactivation of supplementary motor area and thalamus were both correlated with the Improvement of motor function. The result is consistent with the explanation that stimulation in resting patients raises output from the STN with activation of the inhibitory basal ganglia output nuclei and subsequent deactivation of the thalamic anteroventral and ventrolateral nuclei and the supplementary motor area. Hum Brain Mapp 30:112-121, 2009.

Original languageEnglish (US)
Pages (from-to)112-121
Number of pages10
JournalHuman Brain Mapping
Volume30
Issue number1
DOIs
StatePublished - Jan 2009
Externally publishedYes

Fingerprint

Corpus Striatum
Subthalamic Nucleus
Parkinson Disease
Motor Cortex
Basal Ganglia
Thalamus
Cerebrovascular Circulation
Anterior Thalamic Nuclei
Ventral Thalamic Nuclei
Antiparkinson Agents
Deep Brain Stimulation
Regional Blood Flow
Brain
Cerebellum

Keywords

  • Basalgangglia loop
  • Clinical outcome
  • Deactivation
  • Flow
  • Parkinson
  • PET
  • STN-stimulation
  • Thalamus
  • VL

ASJC Scopus subject areas

  • Clinical Neurology
  • Anatomy
  • Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

STN-Stimulation in Parkinson's disease restores striatal inhibition of thalamocortical projection. / Geday, Jacob; Østergaard, Karen; Johnsen, Erik; Gjedde, Albert.

In: Human Brain Mapping, Vol. 30, No. 1, 01.2009, p. 112-121.

Research output: Contribution to journalArticle

Geday, Jacob ; Østergaard, Karen ; Johnsen, Erik ; Gjedde, Albert. / STN-Stimulation in Parkinson's disease restores striatal inhibition of thalamocortical projection. In: Human Brain Mapping. 2009 ; Vol. 30, No. 1. pp. 112-121.
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