TY - JOUR
T1 - Stimulus type affects Wada memory performance
AU - Testa, S. Marc
AU - Ward, Julianna
AU - Crone, Nathan E.
AU - Brandt, Jason
N1 - Funding Information:
This study was made possible by the Gertrude A. Sergievsky Research Endowment supported by the Epilepsy Foundation Behavioral Sciences Postdoctoral Fellowship (S.M.T.). This study was presented at the 35th Annual Meeting of the International Neuropsychological Society, Portland, Oregon, USA, 2007. We thank Robin Sue Miller, M.S., for her valuable assistance recording data during the Wada procedures, as well as the faculty and staff of the Johns Hopkins University Epilepsy Center. We also acknowledge the very helpful comments and suggestions made by the reviewers.
PY - 2008/10
Y1 - 2008/10
N2 - The effects of amytal injection side, seizure focus laterality, and stimulus type (real and line-drawn objects, printed words, and faces) on recognition memory were studied during the Wada procedure. To-be-remembered stimuli were presented during cerebral anesthesia to 35 patients with left temporal lobe epilepsy (LTLE) and 28 patients with right temporal lobe epilepsy (RTLE), all with left hemisphere language dominance. In both groups, recognition of real and line-drawn objects was best after anesthetization of the lesional hemisphere. Recognition of faces was poor after either injection in patients with RTLE, but only after right injection in patients with LTLE. Conversely, recognition of words by patients with LTLE was impaired equally after either injection, but more so after left than right injection in patients with RTLE. The findings suggest that (1) real and line-drawn objects are "dually encoded" and memory accuracy depends on seizure focus laterality, and (2) accuracy in recognition of words and faces is related to seizure focus laterality, but may also depend on the language dominance of the hemisphere being assessed.
AB - The effects of amytal injection side, seizure focus laterality, and stimulus type (real and line-drawn objects, printed words, and faces) on recognition memory were studied during the Wada procedure. To-be-remembered stimuli were presented during cerebral anesthesia to 35 patients with left temporal lobe epilepsy (LTLE) and 28 patients with right temporal lobe epilepsy (RTLE), all with left hemisphere language dominance. In both groups, recognition of real and line-drawn objects was best after anesthetization of the lesional hemisphere. Recognition of faces was poor after either injection in patients with RTLE, but only after right injection in patients with LTLE. Conversely, recognition of words by patients with LTLE was impaired equally after either injection, but more so after left than right injection in patients with RTLE. The findings suggest that (1) real and line-drawn objects are "dually encoded" and memory accuracy depends on seizure focus laterality, and (2) accuracy in recognition of words and faces is related to seizure focus laterality, but may also depend on the language dominance of the hemisphere being assessed.
KW - Functional laterality
KW - Intracarotid amobarbital procedure
KW - Language dominance
KW - Material-specific memory
KW - Temporal lobe epilepsy
KW - Wada
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U2 - 10.1016/j.yebeh.2008.06.020
DO - 10.1016/j.yebeh.2008.06.020
M3 - Article
C2 - 18639650
AN - SCOPUS:50849104756
SN - 1525-5050
VL - 13
SP - 458
EP - 462
JO - Epilepsy and Behavior
JF - Epilepsy and Behavior
IS - 3
ER -