Abstract
Splenopentin (SP-5: Arg-Lys-Glu-Val-Tyr), a pentapeptide corresponding to the residues 32-36 of the splenic hormone splenin, increases dose-dependently the number of bone marrow colonies (M and GM colonies). Therefore, we tested the stimulatory effect of SP-5 on the recruitment of epidermal Langerhans cells in skin deprived of these cells. A high dose of cyclophosphamide or dexamethasone led to a drastic decrease of LC density in murine skin with slow and incomplete restoration. SP-5 accelerated Langerhans cell recruitment and led to pretreatment levels of Langerhans cell density in the skin. These results indicate that SP-5 may possibly be used to treat disorders (e.g., HIV infection) where impaired Langerhans cell density and function can lead to secondary cutaneous infections.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 526-529 |
| Number of pages | 4 |
| Journal | Archives of Dermatological Research |
| Volume | 281 |
| Issue number | 8 |
| DOIs | |
| State | Published - Jan 1990 |
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Keywords
- Immunostimulation
- Langerhans cells
- Splenopentin
ASJC Scopus subject areas
- Dermatology
Cite this
Stimulation of the recruitment of epidermal Langerhans cells by splenopentin. / Gruner, S.; Diezel, W.; Strunk, D.; Zwirner, A.; Sönnichsen, N.; Anhalt, Grant James.
In: Archives of Dermatological Research, Vol. 281, No. 8, 01.1990, p. 526-529.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Stimulation of the recruitment of epidermal Langerhans cells by splenopentin
AU - Gruner, S.
AU - Diezel, W.
AU - Strunk, D.
AU - Zwirner, A.
AU - Sönnichsen, N.
AU - Anhalt, Grant James
PY - 1990/1
Y1 - 1990/1
N2 - Splenopentin (SP-5: Arg-Lys-Glu-Val-Tyr), a pentapeptide corresponding to the residues 32-36 of the splenic hormone splenin, increases dose-dependently the number of bone marrow colonies (M and GM colonies). Therefore, we tested the stimulatory effect of SP-5 on the recruitment of epidermal Langerhans cells in skin deprived of these cells. A high dose of cyclophosphamide or dexamethasone led to a drastic decrease of LC density in murine skin with slow and incomplete restoration. SP-5 accelerated Langerhans cell recruitment and led to pretreatment levels of Langerhans cell density in the skin. These results indicate that SP-5 may possibly be used to treat disorders (e.g., HIV infection) where impaired Langerhans cell density and function can lead to secondary cutaneous infections.
AB - Splenopentin (SP-5: Arg-Lys-Glu-Val-Tyr), a pentapeptide corresponding to the residues 32-36 of the splenic hormone splenin, increases dose-dependently the number of bone marrow colonies (M and GM colonies). Therefore, we tested the stimulatory effect of SP-5 on the recruitment of epidermal Langerhans cells in skin deprived of these cells. A high dose of cyclophosphamide or dexamethasone led to a drastic decrease of LC density in murine skin with slow and incomplete restoration. SP-5 accelerated Langerhans cell recruitment and led to pretreatment levels of Langerhans cell density in the skin. These results indicate that SP-5 may possibly be used to treat disorders (e.g., HIV infection) where impaired Langerhans cell density and function can lead to secondary cutaneous infections.
KW - Immunostimulation
KW - Langerhans cells
KW - Splenopentin
UR - http://www.scopus.com/inward/record.url?scp=0024828057&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024828057&partnerID=8YFLogxK
U2 - 10.1007/BF00412738
DO - 10.1007/BF00412738
M3 - Article
C2 - 2322010
AN - SCOPUS:0024828057
VL - 281
SP - 526
EP - 529
JO - Archives of Dermatological Research
JF - Archives of Dermatological Research
SN - 0340-3696
IS - 8
ER -