Stimulation of the recruitment of epidermal Langerhans cells by splenopentin

S. Gruner, W. Diezel, D. Strunk, A. Zwirner, N. Sönnichsen, G. J. Anhalt

Research output: Contribution to journalArticle

Abstract

Splenopentin (SP-5: Arg-Lys-Glu-Val-Tyr), a pentapeptide corresponding to the residues 32-36 of the splenic hormone splenin, increases dose-dependently the number of bone marrow colonies (M and GM colonies). Therefore, we tested the stimulatory effect of SP-5 on the recruitment of epidermal Langerhans cells in skin deprived of these cells. A high dose of cyclophosphamide or dexamethasone led to a drastic decrease of LC density in murine skin with slow and incomplete restoration. SP-5 accelerated Langerhans cell recruitment and led to pretreatment levels of Langerhans cell density in the skin. These results indicate that SP-5 may possibly be used to treat disorders (e.g., HIV infection) where impaired Langerhans cell density and function can lead to secondary cutaneous infections.

Original languageEnglish (US)
Pages (from-to)526-529
Number of pages4
JournalArchives of Dermatological Research
Volume281
Issue number8
DOIs
StatePublished - Jan 1 1990

Keywords

  • Immunostimulation
  • Langerhans cells
  • Splenopentin

ASJC Scopus subject areas

  • Dermatology

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