Abstract
Splenopentin (SP-5: Arg-Lys-Glu-Val-Tyr), a pentapeptide corresponding to the residues 32-36 of the splenic hormone splenin, increases dose-dependently the number of bone marrow colonies (M and GM colonies). Therefore, we tested the stimulatory effect of SP-5 on the recruitment of epidermal Langerhans cells in skin deprived of these cells. A high dose of cyclophosphamide or dexamethasone led to a drastic decrease of LC density in murine skin with slow and incomplete restoration. SP-5 accelerated Langerhans cell recruitment and led to pretreatment levels of Langerhans cell density in the skin. These results indicate that SP-5 may possibly be used to treat disorders (e.g., HIV infection) where impaired Langerhans cell density and function can lead to secondary cutaneous infections.
Original language | English (US) |
---|---|
Pages (from-to) | 526-529 |
Number of pages | 4 |
Journal | Archives of Dermatological Research |
Volume | 281 |
Issue number | 8 |
DOIs | |
State | Published - Jan 1 1990 |
Keywords
- Immunostimulation
- Langerhans cells
- Splenopentin
ASJC Scopus subject areas
- Dermatology