Stimulation of human PMNs in vitro by a succinimide molecular complex of methylfurylbutyrolactone

Christopher J. Woolverton, Robert W. Veltri, Irvin S. Snyder

Research output: Contribution to journalArticle

Abstract

The immunopotenliating effects on human neutrophils of a new synthetic immune biological response modifer were studied. The compound is a succinimide crystalline molecular complex of methylfurylbutyrolactone (MFBL). The MFBL succinimide (MFBL-S) derivative was tested for its in vitro effects on polymorphonuclear leukocyte (PMN) functions. At microgram quantities, MFBL-S stimulated a twofold increase in: (1) directed migration of PMNs; (2) adherence to nylon; and (3) uptake of E. coli lipopolysaccharide. The MFBL-S enhanced phagocytosis by PMNs of S. epidermidis and E. coli. Additionally, intracellular killing of S. epidermidis by MFBL-S treated PMNs was significantly increased at all doses studied, whereas killing of E. coli was only significantly different from controls at concentrations of 10 μg/ml.

Original languageEnglish (US)
Pages (from-to)527-538
Number of pages12
JournalJournal of Biological Response Modifiers
Volume5
Issue number6
StatePublished - Dec 1986

Keywords

  • Adherence
  • Chemotaxis
  • Immune biological response mediator
  • Phagocytosis
  • Polymorphonuclear leukocytes

ASJC Scopus subject areas

  • Immunology
  • Pharmacology
  • Cancer Research

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