Stimulation of hippocampal neurogenesis by transcranial focused ultrasound and microbubbles in adult mice

Tiffany Scarcelli, Jessica F. Jordão, Meaghan A. O'reilly, Nicholas Ellens, Kullervo Hynynen, Isabelle Aubert

Research output: Contribution to journalArticle

Abstract

Transcranial focused ultrasound (FUS) and microbubble contrast agent, applied at parameters known to transiently increase blood-brain barrier permeability, were tested for the potential to stimulate hippocampal neurogenesis. In adult mice, FUS treatment significantly increased the number of proliferating cells and newborn neurons in the dentate gyrus of the dorsal hippocampus. This provides evidence that FUS with microbubbles can stimulate hippocampal neurogenesis, a process involved in learning and memory and affected in neurological disorders, such as Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)304-307
Number of pages4
JournalBrain Stimulation
Volume7
Issue number2
DOIs
StatePublished - Jan 1 2014

Keywords

  • Astrogenesis
  • Cell proliferation
  • Focused ultrasound
  • Hippocampus
  • Neurogenesis

ASJC Scopus subject areas

  • Biophysics
  • Neuroscience(all)
  • Clinical Neurology

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  • Cite this

    Scarcelli, T., Jordão, J. F., O'reilly, M. A., Ellens, N., Hynynen, K., & Aubert, I. (2014). Stimulation of hippocampal neurogenesis by transcranial focused ultrasound and microbubbles in adult mice. Brain Stimulation, 7(2), 304-307. https://doi.org/10.1016/j.brs.2013.12.012