Stimulation of B Cell Immunity in Flavivirus-Naive Individuals by the Tetravalent Live Attenuated Dengue Vaccine TV003

Huy A. Tu, Usha K. Nivarthi, Nancy R. Graham, Philip Eisenhauer, Matthew J. Delacruz, Kristen K. Pierce, Stephen S. Whitehead, Jonathan E. Boyson, Jason W. Botten, Beth D. Kirkpatrick, Anna P. Durbin, Aravinda M. deSilva, Sean A. Diehl

Research output: Contribution to journalArticlepeer-review

Abstract

Tu et al. show that the protective live attenuated tetravalent dengue vaccine stimulates early B and T cell responses to promote durable memory and neutralizing antibodies.

Original languageEnglish (US)
Article number100155
JournalCell Reports Medicine
Volume1
Issue number9
DOIs
StatePublished - Dec 22 2020

Keywords

  • CD4 T cells
  • dengue vaccine
  • humoral immune response
  • memory B cells
  • neutralizing antibodies
  • protective immunity
  • serotype-specific antibodies
  • tetravalent live attenuated vaccine
  • TV003

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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