Stimulation in the human somatosensory thalamus can reproduce both the affective and sensory dimensions of previously experienced pain

Frederick Lenz, R. H. Gracely, A. J. Romanoski, E. J. Hope, L. H. Rowland, P. M. Dougherty

Research output: Contribution to journalArticle

Abstract

Thalamic structures involved in the unpleasant emotional or affective aspect of pain are poorly understood. We now describe studies of the region of the thalamic principal somatosensory nucleus (Vc) performed before thalamotomy for tremor in a patient who also had panic disorder. Microstimulation in the region posterior to Vc evoked chest pain, including a strong affective dimension, almost identical to that occurring during his panic attacks, as measured using a questionnaire. Results in our other patients indicate that stimulation-associated pain with a strong affective dimension occurred only in those patients who had previously experienced spontaneous pain with a strong affective component. These results are consistent with stimulation-evoked activation of limbic structures, which are connected through cortex with the region posterior to Vc and involved in the affective dimension of pain through conditioning by previous experience.

Original languageEnglish (US)
Pages (from-to)910-913
Number of pages4
JournalNature Medicine
Volume1
Issue number9
StatePublished - 1995

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Thalamus
Chemical activation
Pain
Panic Disorder
Tremor
Chest Pain

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Lenz, F., Gracely, R. H., Romanoski, A. J., Hope, E. J., Rowland, L. H., & Dougherty, P. M. (1995). Stimulation in the human somatosensory thalamus can reproduce both the affective and sensory dimensions of previously experienced pain. Nature Medicine, 1(9), 910-913.

Stimulation in the human somatosensory thalamus can reproduce both the affective and sensory dimensions of previously experienced pain. / Lenz, Frederick; Gracely, R. H.; Romanoski, A. J.; Hope, E. J.; Rowland, L. H.; Dougherty, P. M.

In: Nature Medicine, Vol. 1, No. 9, 1995, p. 910-913.

Research output: Contribution to journalArticle

Lenz, F, Gracely, RH, Romanoski, AJ, Hope, EJ, Rowland, LH & Dougherty, PM 1995, 'Stimulation in the human somatosensory thalamus can reproduce both the affective and sensory dimensions of previously experienced pain', Nature Medicine, vol. 1, no. 9, pp. 910-913.
Lenz, Frederick ; Gracely, R. H. ; Romanoski, A. J. ; Hope, E. J. ; Rowland, L. H. ; Dougherty, P. M. / Stimulation in the human somatosensory thalamus can reproduce both the affective and sensory dimensions of previously experienced pain. In: Nature Medicine. 1995 ; Vol. 1, No. 9. pp. 910-913.
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