Stimulated grip strength measurement: Validation of a novel method for functional assessment

Philip J. Hanwright; Jennifer L. Rath; Nicholas von Guionneau; Thomas G.W. Harris; Karim A. Sarhane; Stephen W.P. Kemp; Ahmet Hoke; Paul S. Cederna; Sami H. Tuffaha

doi:10.1002/mus.26646

Stimulated grip strength measurement: Validation of a novel method for functional assessment

Philip J. Hanwright, Jennifer L. Rath, Nicholas von Guionneau, Thomas G.W. Harris, Karim A. Sarhane, Stephen W.P. Kemp, Ahmet Hoke, Paul S. Cederna, Sami H. Tuffaha

School of Medicine

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Background: Reliable measurement of functional recovery is critical in translational peripheral nerve regeneration research. Behavioral functional assessments such as volitional grip strength testing (vGST) are limited by inherent behavioral variability. Isometric tetanic force testing (ITFT) is highly reliable but precludes serial measurements. Combining elements of vGST and ITFT, stimulated grip strength testing (sGST) involves percutaneous median nerve stimulation to elicit maximal tetanic contraction of digital flexors, thereby allowing for consistent measurement of maximal grip strength. Methods: We measured side-to-side equivalence of force using sGST, vGST, and ITFT to determine relative reliability and repeatability. We also performed weekly force measurements following median nerve repair. Results: sGST demonstrated greater reliability and inter-trial repeatability than vGST and similar reliability to ITFT, with the added benefit of serial measurements. Conclusions: sGST is a valid method for assessing functional recovery that addresses the limitations of the currently available modalities used in translational peripheral nerve regeneration research.

Original language	English (US)
Pages (from-to)	437-442
Number of pages	6
Journal	Muscle and Nerve
Volume	60
Issue number	4
DOIs	https://doi.org/10.1002/mus.26646
State	Published - Oct 1 2019

Keywords

functional assessment
motor reinnervation
muscle force testing
peripheral nerve injury
peripheral nerve regeneration

ASJC Scopus subject areas

Physiology
Clinical Neurology
Cellular and Molecular Neuroscience
Physiology (medical)

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title = "Stimulated grip strength measurement: Validation of a novel method for functional assessment",

abstract = "Background: Reliable measurement of functional recovery is critical in translational peripheral nerve regeneration research. Behavioral functional assessments such as volitional grip strength testing (vGST) are limited by inherent behavioral variability. Isometric tetanic force testing (ITFT) is highly reliable but precludes serial measurements. Combining elements of vGST and ITFT, stimulated grip strength testing (sGST) involves percutaneous median nerve stimulation to elicit maximal tetanic contraction of digital flexors, thereby allowing for consistent measurement of maximal grip strength. Methods: We measured side-to-side equivalence of force using sGST, vGST, and ITFT to determine relative reliability and repeatability. We also performed weekly force measurements following median nerve repair. Results: sGST demonstrated greater reliability and inter-trial repeatability than vGST and similar reliability to ITFT, with the added benefit of serial measurements. Conclusions: sGST is a valid method for assessing functional recovery that addresses the limitations of the currently available modalities used in translational peripheral nerve regeneration research.",

keywords = "functional assessment, motor reinnervation, muscle force testing, peripheral nerve injury, peripheral nerve regeneration",

author = "Hanwright, {Philip J.} and Rath, {Jennifer L.} and {von Guionneau}, Nicholas and Harris, {Thomas G.W.} and Sarhane, {Karim A.} and Kemp, {Stephen W.P.} and Ahmet Hoke and Cederna, {Paul S.} and Tuffaha, {Sami H.}",

note = "Publisher Copyright: {\textcopyright} 2019 Wiley Periodicals, Inc.",

year = "2019",

month = oct,

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doi = "10.1002/mus.26646",

language = "English (US)",

volume = "60",

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T2 - Validation of a novel method for functional assessment

AU - Hanwright, Philip J.

AU - Rath, Jennifer L.

AU - von Guionneau, Nicholas

AU - Harris, Thomas G.W.

AU - Sarhane, Karim A.

AU - Kemp, Stephen W.P.

AU - Hoke, Ahmet

AU - Cederna, Paul S.

AU - Tuffaha, Sami H.

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Background: Reliable measurement of functional recovery is critical in translational peripheral nerve regeneration research. Behavioral functional assessments such as volitional grip strength testing (vGST) are limited by inherent behavioral variability. Isometric tetanic force testing (ITFT) is highly reliable but precludes serial measurements. Combining elements of vGST and ITFT, stimulated grip strength testing (sGST) involves percutaneous median nerve stimulation to elicit maximal tetanic contraction of digital flexors, thereby allowing for consistent measurement of maximal grip strength. Methods: We measured side-to-side equivalence of force using sGST, vGST, and ITFT to determine relative reliability and repeatability. We also performed weekly force measurements following median nerve repair. Results: sGST demonstrated greater reliability and inter-trial repeatability than vGST and similar reliability to ITFT, with the added benefit of serial measurements. Conclusions: sGST is a valid method for assessing functional recovery that addresses the limitations of the currently available modalities used in translational peripheral nerve regeneration research.

AB - Background: Reliable measurement of functional recovery is critical in translational peripheral nerve regeneration research. Behavioral functional assessments such as volitional grip strength testing (vGST) are limited by inherent behavioral variability. Isometric tetanic force testing (ITFT) is highly reliable but precludes serial measurements. Combining elements of vGST and ITFT, stimulated grip strength testing (sGST) involves percutaneous median nerve stimulation to elicit maximal tetanic contraction of digital flexors, thereby allowing for consistent measurement of maximal grip strength. Methods: We measured side-to-side equivalence of force using sGST, vGST, and ITFT to determine relative reliability and repeatability. We also performed weekly force measurements following median nerve repair. Results: sGST demonstrated greater reliability and inter-trial repeatability than vGST and similar reliability to ITFT, with the added benefit of serial measurements. Conclusions: sGST is a valid method for assessing functional recovery that addresses the limitations of the currently available modalities used in translational peripheral nerve regeneration research.

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KW - motor reinnervation

KW - muscle force testing

KW - peripheral nerve injury

KW - peripheral nerve regeneration

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Stimulated grip strength measurement: Validation of a novel method for functional assessment

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