Sticky nanoparticles: A platform for siRNA delivery by a bis(zinc(II) dipicolylamine)-functionalized, self-assembled nanoconjugate

Gang Liu; Ki Young Choi; Ashwinkumar Bhirde; Magdalena Swierczewska; Juan Yin; Sang Wook Lee; Jae Hyung Park; Jong In Hong; Jin Xie; Gang Niu; Dale O. Kiesewetter; Seulki Lee; Xiaoyuan Chen

doi:10.1002/anie.201105565

Sticky nanoparticles: A platform for siRNA delivery by a bis(zinc(II) dipicolylamine)-functionalized, self-assembled nanoconjugate

Gang Liu, Ki Young Choi, Ashwinkumar Bhirde, Magdalena Swierczewska, Juan Yin, Sang Wook Lee, Jae Hyung Park, Jong In Hong, Jin Xie, Gang Niu, Dale O. Kiesewetter, Seulki Lee, Xiaoyuan Chen

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Abstract

Delivering the goods: Multifunctional, self-assembled, polymeric nanoparticles for the simultaneous delivery of small-molecule drugs and siRNA have been synthesized. The nanoparticles are composed of biodegradable hyaluronic acid, for tumor targeting and cellular delivery, and a high siRNA binding affinity is provided by a Zn ^II-dipicolylamine analogue as an artificial phosphate-binding receptor (see scheme).

Original language	English (US)
Pages (from-to)	445-449
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	2
DOIs	https://doi.org/10.1002/anie.201105565
State	Published - Jan 9 2012
Externally published	Yes

Keywords

dipicolylamines
drug delivery
hyaluronic acid
nanoparticles
siRNA

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.201105565

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Liu, G., Choi, K. Y., Bhirde, A., Swierczewska, M., Yin, J., Lee, S. W., Park, J. H., Hong, J. I., Xie, J., Niu, G., Kiesewetter, D. O., Lee, S., & Chen, X. (2012). Sticky nanoparticles: A platform for siRNA delivery by a bis(zinc(II) dipicolylamine)-functionalized, self-assembled nanoconjugate. Angewandte Chemie - International Edition, 51(2), 445-449. https://doi.org/10.1002/anie.201105565

Liu, G, Choi, KY, Bhirde, A, Swierczewska, M, Yin, J, Lee, SW, Park, JH, Hong, JI, Xie, J, Niu, G, Kiesewetter, DO, Lee, S & Chen, X 2012, 'Sticky nanoparticles: A platform for siRNA delivery by a bis(zinc(II) dipicolylamine)-functionalized, self-assembled nanoconjugate', Angewandte Chemie - International Edition, vol. 51, no. 2, pp. 445-449. https://doi.org/10.1002/anie.201105565

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AU - Park, Jae Hyung

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AU - Xie, Jin

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AU - Kiesewetter, Dale O.

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AU - Chen, Xiaoyuan

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Sticky nanoparticles: A platform for siRNA delivery by a bis(zinc(II) dipicolylamine)-functionalized, self-assembled nanoconjugate

Abstract

Keywords

ASJC Scopus subject areas

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