Sticky nanoparticles: A platform for siRNA delivery by a bis(zinc(II) dipicolylamine)-functionalized, self-assembled nanoconjugate

Gang Liu, Ki Young Choi, Ashwinkumar Bhirde, Magdalena Swierczewska, Juan Yin, Sang Wook Lee, Jae Hyung Park, Jong In Hong, Jin Xie, Gang Niu, Dale O. Kiesewetter, Seulki Lee, Xiaoyuan Chen

Research output: Contribution to journalArticlepeer-review

Abstract

Delivering the goods: Multifunctional, self-assembled, polymeric nanoparticles for the simultaneous delivery of small-molecule drugs and siRNA have been synthesized. The nanoparticles are composed of biodegradable hyaluronic acid, for tumor targeting and cellular delivery, and a high siRNA binding affinity is provided by a Zn II-dipicolylamine analogue as an artificial phosphate-binding receptor (see scheme).

Original languageEnglish (US)
Pages (from-to)445-449
Number of pages5
JournalAngewandte Chemie - International Edition
Volume51
Issue number2
DOIs
StatePublished - Jan 9 2012
Externally publishedYes

Keywords

  • dipicolylamines
  • drug delivery
  • hyaluronic acid
  • nanoparticles
  • siRNA

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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