TY - JOUR
T1 - Stevens-Johnson syndrome and toxic epidermal necrolysis
T2 - A review of the literature
AU - Letko, Erik
AU - Papaliodis, Dean N.
AU - Papaliodis, George N.
AU - Daoud, Yassine J.
AU - Ahmed, A. Razzaque
AU - Foster, C. Stephen
N1 - Funding Information:
* Department of Ophthalmology, Uveitis and Immunology Service, The Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts. † Department of Medicine, New England Baptist Hospital, and Department of Oral Medicine and Diagnostic Sciences, Harvard School of Dental Medicine, Boston, Massachusetts. Dr Foster is currently with The Ocular Immunology and Uveitis Foundation, Massachusetts Eye Research and Surgery Institute, Boston, MA. None of the authors have financial interests in any of the medications or products mentioned in this article. Yassine J. Daoud is the recipient of the Doris Duke Charitable Foundation and Harvard Medical School PASTEUR Clinical Research Fellowship. Received for publication April 21, 2004. Accepted for publication in revised form June 21, 2004.
Funding Information:
This feature is supported by an unrestricted educational grant from AstraZeneca LP
PY - 2005/4
Y1 - 2005/4
N2 - Objective: To perform a comprehensive review of Stevens-Johnson syndrome and toxic epidermal necrolysis. Data Sources: A MEDLINE search was performed for the years 1975 to 2003 using the keywords Stevens-Johnson syndrome and toxic epidermal necrolysis to identify relevant articles published in English in peer-reviewed journals. Study Selection: All clinical studies that reported on 4 or more patients, review articles, and experimental studies that concerned disease mechanisms were selected and further analyzed. Clinical reports that included fewer than 4 patients were selected only if they were believed to carry a significant message about disease mechanism or therapy. Results: Stevens-Johnson syndrome and toxic epidermal necrolysis seem to be variants of the same disease with differing severities. A widely accepted consensus regarding diagnostic criteria and therapy does not exist at present. Despite the recent experimental studies, the pathogenic mechanisms of these diseases remain unknown. Although progress in survival through early hospitalization in specialized burn units has been made, the prevalence of life-long disability from the ocular morbidity of Stevens-Johnson syndrome and toxic epidermal necrolysis has remained unchanged for the past 35 years. Further progress depends on modification of the acute phase of the disease rather than continuation of supportive care. The available published evidence indicates that a principal problem in the pathogenesis is immunologic and that immunomodulatory intervention with short-term, high-dose intravenous steroids or intravenous immunoglobulin holds the most promise for effective change in survival and long-term morbidity. Conclusions: The results of this review call for a widely accepted consensus on diagnostic criteria for Stevens-Johnson and toxic epidermal necrolysis and multicenter collaboration in experimental studies and clinical trials that investigate disease mechanisms and novel therapeutic interventions, respectively.
AB - Objective: To perform a comprehensive review of Stevens-Johnson syndrome and toxic epidermal necrolysis. Data Sources: A MEDLINE search was performed for the years 1975 to 2003 using the keywords Stevens-Johnson syndrome and toxic epidermal necrolysis to identify relevant articles published in English in peer-reviewed journals. Study Selection: All clinical studies that reported on 4 or more patients, review articles, and experimental studies that concerned disease mechanisms were selected and further analyzed. Clinical reports that included fewer than 4 patients were selected only if they were believed to carry a significant message about disease mechanism or therapy. Results: Stevens-Johnson syndrome and toxic epidermal necrolysis seem to be variants of the same disease with differing severities. A widely accepted consensus regarding diagnostic criteria and therapy does not exist at present. Despite the recent experimental studies, the pathogenic mechanisms of these diseases remain unknown. Although progress in survival through early hospitalization in specialized burn units has been made, the prevalence of life-long disability from the ocular morbidity of Stevens-Johnson syndrome and toxic epidermal necrolysis has remained unchanged for the past 35 years. Further progress depends on modification of the acute phase of the disease rather than continuation of supportive care. The available published evidence indicates that a principal problem in the pathogenesis is immunologic and that immunomodulatory intervention with short-term, high-dose intravenous steroids or intravenous immunoglobulin holds the most promise for effective change in survival and long-term morbidity. Conclusions: The results of this review call for a widely accepted consensus on diagnostic criteria for Stevens-Johnson and toxic epidermal necrolysis and multicenter collaboration in experimental studies and clinical trials that investigate disease mechanisms and novel therapeutic interventions, respectively.
UR - http://www.scopus.com/inward/record.url?scp=17444381936&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=17444381936&partnerID=8YFLogxK
U2 - 10.1016/S1081-1206(10)61112-X
DO - 10.1016/S1081-1206(10)61112-X
M3 - Review article
C2 - 15875523
AN - SCOPUS:17444381936
SN - 1081-1206
VL - 94
SP - 419
EP - 436
JO - Annals of Allergy, Asthma and Immunology
JF - Annals of Allergy, Asthma and Immunology
IS - 4
ER -