Sterilizing activity of thioridazine in combination with the first-line regimen against acute murine tuberculosis

Noton K. Dutta, Michael L. Pinn, Petros C. Karakousis

Research output: Contribution to journalArticlepeer-review

Abstract

We recently reported that in lung tissue, thioridazine accumulates at high concentrations relative to serum levels, displaying modest synergy with isoniazid and reducing the emergence of isoniazid-resistant mutants in mouse lungs. In this study, we sought to investigate the sterilizing activity of human-equivalent doses of thioridazine when given in combination with the "Denver regimen" against acute murine tuberculosis. We found a trend toward a positive impact of thioridazine on the bacterial clearance and lowering relapse rates of the combined standard TB chemotherapy.

Original languageEnglish (US)
Pages (from-to)5567-5569
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume58
Issue number9
DOIs
StatePublished - Sep 2014

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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