EFFICACITE STERILISANTE DE L'ISONIAZIDE ET DU PYRAZINAMIDE EN ASSOCIATION AVEC LA RIFAMPICINE DANS LA TUBERCULOSE EXPERIMENTALE DE LA SOURIS

Translated title of the contribution: Sterilizing activity of isoniazid and pyrazinamide in combination with rifampicin in the experimental tuberculosis of the mouse

J. Grosset, Ch Truffot, C. Boval, J. Fermanian

Research output: Contribution to journalArticle

Abstract

Mice inoculated with M. tuberculosis were treated for the 3 initial months with a combination of rifampicin (RMP) and isoniazid (INH). For the 3 following months, they were treated with either RMP alone or RMP + INH or RMP + INH + pyrazinamide (PZA). After 6 months of follow-up without treatment, there were 66%, 60% and 58% of lung and/or spleen positive cultures in the mice that received, respectively, RMP alone, RMP + INH or RMP + INH + PZA for the last 3 months. There is no evidence that adding either INH or INH + PZA to RMP in the continuation phase of treatment conferred a benefit over RMP alone.

Translated title of the contributionSterilizing activity of isoniazid and pyrazinamide in combination with rifampicin in the experimental tuberculosis of the mouse
Original languageFrench
Pages (from-to)31-32
Number of pages2
JournalRevue Francaise des Maladies Respiratoires
Volume8
Issue number1
StatePublished - Jan 1 1980

ASJC Scopus subject areas

  • Medicine(all)

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