EFFICACITE STERILISANTE DE L'ISONIAZIDE ET DU PYRAZINAMIDE EN ASSOCIATION AVEC LA RIFAMPICINE DANS LA TUBERCULOSE EXPERIMENTALE DE LA SOURIS

J. Grosset; Ch Truffot; C. Boval; J. Fermanian

EFFICACITE STERILISANTE DE L'ISONIAZIDE ET DU PYRAZINAMIDE EN ASSOCIATION AVEC LA RIFAMPICINE DANS LA TUBERCULOSE EXPERIMENTALE DE LA SOURIS

Translated title of the contribution: Sterilizing activity of isoniazid and pyrazinamide in combination with rifampicin in the experimental tuberculosis of the mouse

J. Grosset, Ch Truffot, C. Boval, J. Fermanian

Research output: Contribution to journal › Article › peer-review

Abstract

Mice inoculated with M. tuberculosis were treated for the 3 initial months with a combination of rifampicin (RMP) and isoniazid (INH). For the 3 following months, they were treated with either RMP alone or RMP + INH or RMP + INH + pyrazinamide (PZA). After 6 months of follow-up without treatment, there were 66%, 60% and 58% of lung and/or spleen positive cultures in the mice that received, respectively, RMP alone, RMP + INH or RMP + INH + PZA for the last 3 months. There is no evidence that adding either INH or INH + PZA to RMP in the continuation phase of treatment conferred a benefit over RMP alone.

Translated title of the contribution	Sterilizing activity of isoniazid and pyrazinamide in combination with rifampicin in the experimental tuberculosis of the mouse
Original language	French
Pages (from-to)	31-32
Number of pages	2
Journal	Revue Francaise des Maladies Respiratoires
Volume	8
Issue number	1
State	Published - 1980
Externally published	Yes

ASJC Scopus subject areas

General Medicine

Cite this

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title = "EFFICACITE STERILISANTE DE L'ISONIAZIDE ET DU PYRAZINAMIDE EN ASSOCIATION AVEC LA RIFAMPICINE DANS LA TUBERCULOSE EXPERIMENTALE DE LA SOURIS",

abstract = "Mice inoculated with M. tuberculosis were treated for the 3 initial months with a combination of rifampicin (RMP) and isoniazid (INH). For the 3 following months, they were treated with either RMP alone or RMP + INH or RMP + INH + pyrazinamide (PZA). After 6 months of follow-up without treatment, there were 66%, 60% and 58% of lung and/or spleen positive cultures in the mice that received, respectively, RMP alone, RMP + INH or RMP + INH + PZA for the last 3 months. There is no evidence that adding either INH or INH + PZA to RMP in the continuation phase of treatment conferred a benefit over RMP alone.",

author = "J. Grosset and Ch Truffot and C. Boval and J. Fermanian",

year = "1980",

language = "French",

volume = "8",

pages = "31--32",

journal = "Revue Francaise des Maladies Respiratoires",

issn = "0301-0279",

publisher = "Elsevier Masson",

number = "1",

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T1 - EFFICACITE STERILISANTE DE L'ISONIAZIDE ET DU PYRAZINAMIDE EN ASSOCIATION AVEC LA RIFAMPICINE DANS LA TUBERCULOSE EXPERIMENTALE DE LA SOURIS

AU - Grosset, J.

AU - Truffot, Ch

AU - Boval, C.

AU - Fermanian, J.

PY - 1980

Y1 - 1980

N2 - Mice inoculated with M. tuberculosis were treated for the 3 initial months with a combination of rifampicin (RMP) and isoniazid (INH). For the 3 following months, they were treated with either RMP alone or RMP + INH or RMP + INH + pyrazinamide (PZA). After 6 months of follow-up without treatment, there were 66%, 60% and 58% of lung and/or spleen positive cultures in the mice that received, respectively, RMP alone, RMP + INH or RMP + INH + PZA for the last 3 months. There is no evidence that adding either INH or INH + PZA to RMP in the continuation phase of treatment conferred a benefit over RMP alone.

AB - Mice inoculated with M. tuberculosis were treated for the 3 initial months with a combination of rifampicin (RMP) and isoniazid (INH). For the 3 following months, they were treated with either RMP alone or RMP + INH or RMP + INH + pyrazinamide (PZA). After 6 months of follow-up without treatment, there were 66%, 60% and 58% of lung and/or spleen positive cultures in the mice that received, respectively, RMP alone, RMP + INH or RMP + INH + PZA for the last 3 months. There is no evidence that adding either INH or INH + PZA to RMP in the continuation phase of treatment conferred a benefit over RMP alone.

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M3 - Article

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SN - 0301-0279

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JO - Revue Francaise des Maladies Respiratoires

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EFFICACITE STERILISANTE DE L'ISONIAZIDE ET DU PYRAZINAMIDE EN ASSOCIATION AVEC LA RIFAMPICINE DANS LA TUBERCULOSE EXPERIMENTALE DE LA SOURIS

Abstract

ASJC Scopus subject areas

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