Sterility in male animals induced by injection of chemical agents into the vas deferens

C. Freeman, D. S. Coffey

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


A new approach to rapid male sterilization has been developed in rats, dogs, and human cadavers. This procedure involves injection of chemical agents directly into the vas deferens, resulting in an obstructing scar within the lumen of the vas deferens. A wide variety of chemical agents has been tested in a large series of animals and several of these agents appear to produce complete blockage of the vas, as determined by mating studies, microscopic examination of ejaculates, and histologic findings in the vas deferens. It is believed that this technique can be developed into a rapid, nonsurgical method of producing human male sterility, with particular application to large scale voluntary sterilization programs in less developed countries. However, further testing will be required to demonstrate the permanency of this procedure.

Original languageEnglish (US)
Pages (from-to)884-890
Number of pages7
JournalFertility and sterility
Issue number11
StatePublished - 1973
Externally publishedYes

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology


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