Stereotactic radiation for spinal metastases

R. Kumar, Sara Alcorn, A. Sahgal, Kristin A Redmond

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Spinal metastases remain a common problem in the natural history of multiple malignancies. Historically, conventionally fractionated radiation has been used in the palliative setting to reduce pain and/or neurologic symptoms; however, results may not be complete or durable, particularly for long-term survivors. Stereotactic body radiotherapy (SBRT) for spinal metastases represents an evolving paradigm shift in the field of palliative radiotherapy. Utilizing higher dose per fraction radiation, this modality increases both the biologically effective dose and conformality of the radiation dose distribution, thereby potentially improving local disease control and reducing side effects. Retrospective and prospective studies suggest excellent local control and pain control with an acceptable toxicity profile. In this chapter, the data supporting SBRT in spine metastases will be described and compared to conventionally fractionated, non-stereotactic radiation including a review of toxicities unique to spine SBRT. The treatment technique of spine SBRT, including appropriate patient selection, prescription dose normal tissue constraints, common side effects, and contraindications to its use will also be described in detail.

Original languageEnglish (US)
Title of host publicationPalliative Radiation Therapy: Utilization of Advanced Technologies
PublisherNova Science Publishers, Inc.
Pages227-244
Number of pages18
Volume1
ISBN (Print)9781634823272, 9781634636346
StatePublished - Apr 1 2015

Fingerprint

Radiosurgery
Radiation
Neoplasm Metastasis
Spine
Pain
Neurologic Manifestations
Patient Selection
Prescriptions
Survivors
Radiotherapy
Retrospective Studies
Prospective Studies
Neoplasms
Therapeutics

Keywords

  • Cyberknife
  • Linear accelerator
  • Metastases
  • Metastasis
  • Radiation
  • SABR
  • SBRT
  • Spinal cord
  • Spine
  • SRS
  • Stereotactic

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kumar, R., Alcorn, S., Sahgal, A., & Redmond, K. A. (2015). Stereotactic radiation for spinal metastases. In Palliative Radiation Therapy: Utilization of Advanced Technologies (Vol. 1, pp. 227-244). Nova Science Publishers, Inc..

Stereotactic radiation for spinal metastases. / Kumar, R.; Alcorn, Sara; Sahgal, A.; Redmond, Kristin A.

Palliative Radiation Therapy: Utilization of Advanced Technologies. Vol. 1 Nova Science Publishers, Inc., 2015. p. 227-244.

Research output: Chapter in Book/Report/Conference proceedingChapter

Kumar, R, Alcorn, S, Sahgal, A & Redmond, KA 2015, Stereotactic radiation for spinal metastases. in Palliative Radiation Therapy: Utilization of Advanced Technologies. vol. 1, Nova Science Publishers, Inc., pp. 227-244.
Kumar R, Alcorn S, Sahgal A, Redmond KA. Stereotactic radiation for spinal metastases. In Palliative Radiation Therapy: Utilization of Advanced Technologies. Vol. 1. Nova Science Publishers, Inc. 2015. p. 227-244
Kumar, R. ; Alcorn, Sara ; Sahgal, A. ; Redmond, Kristin A. / Stereotactic radiation for spinal metastases. Palliative Radiation Therapy: Utilization of Advanced Technologies. Vol. 1 Nova Science Publishers, Inc., 2015. pp. 227-244
@inbook{8b257d94591b4632abc52278debd89d0,
title = "Stereotactic radiation for spinal metastases",
abstract = "Spinal metastases remain a common problem in the natural history of multiple malignancies. Historically, conventionally fractionated radiation has been used in the palliative setting to reduce pain and/or neurologic symptoms; however, results may not be complete or durable, particularly for long-term survivors. Stereotactic body radiotherapy (SBRT) for spinal metastases represents an evolving paradigm shift in the field of palliative radiotherapy. Utilizing higher dose per fraction radiation, this modality increases both the biologically effective dose and conformality of the radiation dose distribution, thereby potentially improving local disease control and reducing side effects. Retrospective and prospective studies suggest excellent local control and pain control with an acceptable toxicity profile. In this chapter, the data supporting SBRT in spine metastases will be described and compared to conventionally fractionated, non-stereotactic radiation including a review of toxicities unique to spine SBRT. The treatment technique of spine SBRT, including appropriate patient selection, prescription dose normal tissue constraints, common side effects, and contraindications to its use will also be described in detail.",
keywords = "Cyberknife, Linear accelerator, Metastases, Metastasis, Radiation, SABR, SBRT, Spinal cord, Spine, SRS, Stereotactic",
author = "R. Kumar and Sara Alcorn and A. Sahgal and Redmond, {Kristin A}",
year = "2015",
month = "4",
day = "1",
language = "English (US)",
isbn = "9781634823272",
volume = "1",
pages = "227--244",
booktitle = "Palliative Radiation Therapy: Utilization of Advanced Technologies",
publisher = "Nova Science Publishers, Inc.",

}

TY - CHAP

T1 - Stereotactic radiation for spinal metastases

AU - Kumar, R.

AU - Alcorn, Sara

AU - Sahgal, A.

AU - Redmond, Kristin A

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Spinal metastases remain a common problem in the natural history of multiple malignancies. Historically, conventionally fractionated radiation has been used in the palliative setting to reduce pain and/or neurologic symptoms; however, results may not be complete or durable, particularly for long-term survivors. Stereotactic body radiotherapy (SBRT) for spinal metastases represents an evolving paradigm shift in the field of palliative radiotherapy. Utilizing higher dose per fraction radiation, this modality increases both the biologically effective dose and conformality of the radiation dose distribution, thereby potentially improving local disease control and reducing side effects. Retrospective and prospective studies suggest excellent local control and pain control with an acceptable toxicity profile. In this chapter, the data supporting SBRT in spine metastases will be described and compared to conventionally fractionated, non-stereotactic radiation including a review of toxicities unique to spine SBRT. The treatment technique of spine SBRT, including appropriate patient selection, prescription dose normal tissue constraints, common side effects, and contraindications to its use will also be described in detail.

AB - Spinal metastases remain a common problem in the natural history of multiple malignancies. Historically, conventionally fractionated radiation has been used in the palliative setting to reduce pain and/or neurologic symptoms; however, results may not be complete or durable, particularly for long-term survivors. Stereotactic body radiotherapy (SBRT) for spinal metastases represents an evolving paradigm shift in the field of palliative radiotherapy. Utilizing higher dose per fraction radiation, this modality increases both the biologically effective dose and conformality of the radiation dose distribution, thereby potentially improving local disease control and reducing side effects. Retrospective and prospective studies suggest excellent local control and pain control with an acceptable toxicity profile. In this chapter, the data supporting SBRT in spine metastases will be described and compared to conventionally fractionated, non-stereotactic radiation including a review of toxicities unique to spine SBRT. The treatment technique of spine SBRT, including appropriate patient selection, prescription dose normal tissue constraints, common side effects, and contraindications to its use will also be described in detail.

KW - Cyberknife

KW - Linear accelerator

KW - Metastases

KW - Metastasis

KW - Radiation

KW - SABR

KW - SBRT

KW - Spinal cord

KW - Spine

KW - SRS

KW - Stereotactic

UR - http://www.scopus.com/inward/record.url?scp=84956789830&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84956789830&partnerID=8YFLogxK

M3 - Chapter

AN - SCOPUS:84956789830

SN - 9781634823272

SN - 9781634636346

VL - 1

SP - 227

EP - 244

BT - Palliative Radiation Therapy: Utilization of Advanced Technologies

PB - Nova Science Publishers, Inc.

ER -