Stereotactic body radiation therapy with concurrent full-dose gemcitabine for locally advanced pancreatic cancer: A pilot trial demonstrating safety

Marie K. Gurka, Sean P. Collins, Rebecca Slack, Gary Tse, Aline Charabaty, Lisa Ley, Liam Berzcel, Siyuan Lei, Simeng Suy, Nadim Haddad, Reena Jha, Colin D. Johnson, Patrick Jackson, John L. Marshall, Michael J. Pishvaian

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Abstract

Background: Concurrent chemoradiation is a standard option for locally advanced pancreatic cancer (LAPC). Concurrent conventional radiation with full-dose gemcitabine has significant toxicity. Stereotactic body radiation therapy (SBRT) may provide the opportunity to administer radiation in a shorter time frame with similar efficacy and reduced toxicity. This Pilot study assessed the safety of concurrent full-dose gemcitabine with SBRT for LAPC.Methods: Patients received gemcitabine, 1000 mg/m2 for 6 cycles. During week 4 of cycle 1, patients received SBRT (25 Gy delivered in five consecutive daily fractions of 5 Gy prescribed to the 75-83% isodose line). Acute and late toxicities were assessed using NIH CTCAE v3. Tumor response was assessed by RECIST. Patients underwent an esophagogastroduodenoscopy at baseline, 2, and 6 months to assess the duodenal mucosa. Quality of life (QoL) data was collected before and after treatment using the QLQ-C30 and QLQ-PAN26 questionnaires.Results: Between September 2009 and February 2011, 11 patients enrolled with one withdrawal during radiation therapy. Patients had grade 1 to 2 gastrointestinal toxicity from the start of SBRT to 2 weeks after treatment. There were no grade 3 or greater radiation-related toxicities or delays for cycle 2 of gemcitabine. On endoscopy, there were no grade 2 or higher mucosal toxicities. Two patients had a partial response. The median progression free and overall survival were 6.8 and 12.2 months, respectively. Global QoL did not change between baseline and immediately after radiation treatment.Conclusions: SBRT with concurrent full dose gemcitabine is safe when administered to patients with LAPC. There is no delay in administration of radiation or chemotherapy, and radiation is completed with minimal toxicity.

Original languageEnglish (US)
Article number44
JournalRadiation Oncology
Volume8
Issue number1
DOIs
StatePublished - Mar 1 2013
Externally publishedYes

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Keywords

  • CyberKnife
  • Gemcitabine
  • Pancreatic cancer
  • QLQ-C30
  • QLQ-PAN26
  • Quality of life
  • Radiation
  • SBRT
  • Stereotactic body radiation therapy
  • Upper endoscopy

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

Gurka, M. K., Collins, S. P., Slack, R., Tse, G., Charabaty, A., Ley, L., Berzcel, L., Lei, S., Suy, S., Haddad, N., Jha, R., Johnson, C. D., Jackson, P., Marshall, J. L., & Pishvaian, M. J. (2013). Stereotactic body radiation therapy with concurrent full-dose gemcitabine for locally advanced pancreatic cancer: A pilot trial demonstrating safety. Radiation Oncology, 8(1), [44]. https://doi.org/10.1186/1748-717X-8-44