Stereospecificity of interaction of neuroleptic drugs with neurotransmitters and correlation with clinical potency

S. J. Enna, J. P. Bennett, D. R. Burt, I. Creese, Solomon H. Snyder

Research output: Contribution to journalArticlepeer-review

Abstract

THE molecular mechanism responsible for the therapeutic activity of a drug is often suggested by the biochemical event which correlates best with clinical potency. Thus, if optical or geometrical isomers of a drug have markedly different clinical potencies, the most relevant biochemical effect should also exhibit isomeric specificity.

Original languageEnglish (US)
Pages (from-to)338-341
Number of pages4
JournalNature
Volume263
Issue number5575
DOIs
StatePublished - Dec 1 1976

ASJC Scopus subject areas

  • General

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