Stereospecific metabolism of itraconazole by CYP3A4: Dioxolane ring scission of azole antifungals

Medicine & Life Sciences

• formal glycol 100%
• Azoles 70%
• Itraconazole 66%
• Cytochrome P-450 CYP3A 63%
• Triazoles 20%
• hydroxide ion 8%
• Heme 8%
• Cytochrome P-450 CYP3A Inhibitors 5%
• Catalysis 4%
• Hydroxylation 4%
• Midazolam 4%
• Metabolic Networks and Pathways 3%
• Nitrogen 3%
• Catalytic Domain 3%
• Iron 3%
• Urine 2%
• Pharmaceutical Preparations 1%

Chemical Compounds

• Itraconazole 82%
• Azole 67%
• Pharmacological Metabolism 42%
• Triazole 33%
• Stereoisomer 32%
• Heme 14%
• Midazolam 11%
• Dissociation 11%
• Mixture 6%
• Metabolic 6%
• Compound Isomer 5%
• Catalysis 5%
• Nitrogen 4%
• Drug 4%