Stereoselective synthesis of (3R,4S)-3-amino-4-methyl pyrrolidine

G. Jayachitra; Ravi Kumar Anchoori; B. Venkateswara Rao

doi:10.1016/j.tetasy.2008.10.005

Stereoselective synthesis of (3R,4S)-3-amino-4-methyl pyrrolidine

G. Jayachitra, Ravi Kumar Anchoori, B. Venkateswara Rao

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A stereoselective approach for the synthesis of (3R,4S)-3-amino-4-methyl pyrrolidine, a part of the structure of a quinoline antibacterial compound and the naphthyridine antitumor agent, is described. The key reaction is the one-pot reduction and regioselective cyclization of azidoditosyl derivative 9 to pyrrolidine 10.

Original language	English (US)
Pages (from-to)	2402-2405
Number of pages	4
Journal	Tetrahedron Asymmetry
Volume	19
Issue number	20
DOIs	https://doi.org/10.1016/j.tetasy.2008.10.005
State	Published - Oct 20 2008
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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10.1016/j.tetasy.2008.10.005

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title = "Stereoselective synthesis of (3R,4S)-3-amino-4-methyl pyrrolidine",

abstract = "A stereoselective approach for the synthesis of (3R,4S)-3-amino-4-methyl pyrrolidine, a part of the structure of a quinoline antibacterial compound and the naphthyridine antitumor agent, is described. The key reaction is the one-pot reduction and regioselective cyclization of azidoditosyl derivative 9 to pyrrolidine 10.",

author = "G. Jayachitra and Anchoori, {Ravi Kumar} and Rao, {B. Venkateswara}",

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AU - Jayachitra, G.

AU - Anchoori, Ravi Kumar

AU - Rao, B. Venkateswara

PY - 2008/10/20

Y1 - 2008/10/20

N2 - A stereoselective approach for the synthesis of (3R,4S)-3-amino-4-methyl pyrrolidine, a part of the structure of a quinoline antibacterial compound and the naphthyridine antitumor agent, is described. The key reaction is the one-pot reduction and regioselective cyclization of azidoditosyl derivative 9 to pyrrolidine 10.

AB - A stereoselective approach for the synthesis of (3R,4S)-3-amino-4-methyl pyrrolidine, a part of the structure of a quinoline antibacterial compound and the naphthyridine antitumor agent, is described. The key reaction is the one-pot reduction and regioselective cyclization of azidoditosyl derivative 9 to pyrrolidine 10.

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M3 - Article

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EP - 2405

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JF - Tetrahedron Asymmetry

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ER -

Stereoselective synthesis of (3R,4S)-3-amino-4-methyl pyrrolidine

Abstract

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