Stereoselective synthesis and biological studies of the C2 and C3 epimer and the enantiomer of pachastrissamine (Jaspine B)

G. Jayachitra, N. Sudhakar, Ravi Kumar Anchoori, B. Venkateswara Rao, Sayantani Roy, Rajkumar Banerjee

Research output: Contribution to journalArticlepeer-review

Abstract

The synthesis of the C2 and C3 epimer and also the enantiomer of jaspine B from d-glucose is reported. The cytotoxicity of these isomers along with jaspine B and its C2 epimer on MCF7 cells has been correlated with commercially available anticancer drug Epirubicin.

Original languageEnglish (US)
Pages (from-to)115-119
Number of pages5
JournalSynthesis
Issue number1
DOIs
StatePublished - 2010
Externally publishedYes

Keywords

  • Cytotoxicity
  • D-glucose
  • Jaspine B
  • Mitsunobu inversion
  • Pachastrissamine
  • Wittig olefination

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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