Stereoselective and nonstereoselective pharmacokinetics of rabeprazole–an overview

Ranjeet Prasad Dash, Rana Rais, Nuggehally R. Srinivas

Research output: Contribution to journalReview articlepeer-review

Abstract

1.Proton pump inhibitors have been extensively used for the treatment of ailments due to increased gastric acid secretion such as peptic ulcers, gastroesophageal reflux disease, etc. 2.There are several approved drugs in the proton pump inhibitor class with the latest entries representing single enantiomer drugs of the previously approved racemic drugs. 3.Despite having a high degree of structural resemblance, rabeprazole, was shown to possess some unique differentiation from other drugs in the class. One of the key distinguishing features of rabeprazole was related to the lesser involvement of polymorphic metabolism in its pharmacokinetic disposition. 4.The review was aimed to provide pharmacokinetic data of rabeprazole from several clinical studies including drug–drug interaction studies where rabeprazole was either a perpetrator drug or victim drug. 5.Additional perspectives on therapy considerations due to the unique metabolic disposition of rabeprazole including the possible issues related to chirality were provided.

Original languageEnglish (US)
Pages (from-to)422-432
Number of pages11
JournalXenobiotica
Volume48
Issue number4
DOIs
StatePublished - Apr 3 2018

Keywords

  • Clinical
  • drug interaction
  • enantiomer
  • pharmacokinetics
  • rabeprazole

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Health, Toxicology and Mutagenesis

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