Stent thrombosis associated with first-generation drug-eluting stents: Issues with antiplatelet therapy

P. A. Gurbel, D. E. Kandzari

Research output: Contribution to journalArticle

Abstract

Notice of the rare but catastrophic occurrence of stent thrombosis in association with deployment of drug-eluting stents has focused attention on the adequacy of the current dual antiplatelet regimen of aspirin and clopidogrel. Some patients will not respond to clopidogrel and a glycoprotein (GP) IIb/IIIa inhibitor may be strongly considered during stenting procedures, especially in high-risk patients or those not receiving pretreatment with clopidogrel. Insisting upon and confirming adherence to antiplatelet therapy are complicated tasks, especially because the reasons for premature discontinuation are myriad, from cost to bleeding complications to the need for minor surgery. Nevertheless, the concern about adherence to antiplatelet therapy represents a new and significant clinical reality in our stenting era, one previously less appreciated with the deployment of bare metal stents.

Original languageEnglish (US)
Pages (from-to)148-150
Number of pages3
JournalNetherlands Heart Journal
Volume15
Issue number4
DOIs
StatePublished - Apr 2007

Keywords

  • Platelet aggregation inhibitors
  • Stents (drug-eluting)
  • Thrombosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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