Stem cells, their niches and the systemic environment: An aging network

Research output: Contribution to journalReview article


Stem cells have a fascinating biology and offer great prospects for therapeutic applications, stimulating intense research on what controls their properties and behavior. Although there have been significant advances in our understanding of how local microenvironments, or niches, control the maintenance and activity of stem cells, it is much less well understood how stem cells sense and respond to variable external, physiological, or tissue environments. This review focuses on the multidirectional interactions among stem cells, niches, tissues, and the systemic environment and on potential ideas for how changes in this network of communication may relate to the aging process.

Original languageEnglish (US)
Pages (from-to)1787-1797
Number of pages11
Issue number4
StatePublished - Dec 1 2008
Externally publishedYes


ASJC Scopus subject areas

  • Genetics

Cite this