TY - JOUR
T1 - Stem cells, multiorgan failure in radiation emergency medical preparedness
T2 - A U.S./European Consultation Workshop
AU - Fliedner, Theodor M.
AU - Chao, Nelson J.
AU - Bader, Judith L.
AU - Boettger, Axel
AU - Case, Cullen
AU - Chute, John
AU - Confer, Dennis L.
AU - Ganser, Arnold
AU - Gorin, Norbert Claude
AU - Gourmelon, Patrick
AU - Graessle, Dieter H.
AU - Krawisz, Robert
AU - Meineke, Viktor
AU - Niederwieser, Dietger
AU - Port, Matthias
AU - Powles, Ray
AU - Sirohi, Bhawna
AU - Weinstock, David M.
AU - Wiley, Albert
AU - Coleman, C. Norman
PY - 2009/5
Y1 - 2009/5
N2 - The concern of the public regarding terrorist actions involving nuclear emergencies resulted in the reopening of the discussion regarding the best ways to cope with the inevitable health impairments. Medical experts from the US and from Europe considered it of importance to harmonize at an international level the diagnostic and therapeutic approaches regarding the radiation-induced health impairments. The present contribution is the result of the first U.S./European Consultation Workshop addressing approaches to radiation emergency preparedness and assistance, which was held recently at Ulm University, Ulm, Germany. Discussions dealt with the assessment of the extent of damage after total body exposure and, in particular, the quantity and quality of the damage to the hematopoietic stem cell pool. Secondly, the pathogenesis of the multiorgan failure was considered because of the organ-to-organ interactions. Thirdly, approaches were considered to harmonize the "triage-methods" used on an international level using the "Response Category" approach as developed for the European Communities. These discussions lead to the conclusion that there is a strong need for continuing education of physicians, nurses, and support personnel to address the issues posed by the management of patients suffering from radiation syndromes. Finally, the discussions expressed the need for more international cooperation in research and development of more refined methods to treat patients with any type of radiation syndromes.
AB - The concern of the public regarding terrorist actions involving nuclear emergencies resulted in the reopening of the discussion regarding the best ways to cope with the inevitable health impairments. Medical experts from the US and from Europe considered it of importance to harmonize at an international level the diagnostic and therapeutic approaches regarding the radiation-induced health impairments. The present contribution is the result of the first U.S./European Consultation Workshop addressing approaches to radiation emergency preparedness and assistance, which was held recently at Ulm University, Ulm, Germany. Discussions dealt with the assessment of the extent of damage after total body exposure and, in particular, the quantity and quality of the damage to the hematopoietic stem cell pool. Secondly, the pathogenesis of the multiorgan failure was considered because of the organ-to-organ interactions. Thirdly, approaches were considered to harmonize the "triage-methods" used on an international level using the "Response Category" approach as developed for the European Communities. These discussions lead to the conclusion that there is a strong need for continuing education of physicians, nurses, and support personnel to address the issues posed by the management of patients suffering from radiation syndromes. Finally, the discussions expressed the need for more international cooperation in research and development of more refined methods to treat patients with any type of radiation syndromes.
KW - Hemopoietic growth factor
KW - Irradiation
KW - Stem cell transplantation
KW - Stem cell-microenvironment interactions
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U2 - 10.1002/stem.16
DO - 10.1002/stem.16
M3 - Article
C2 - 19418462
AN - SCOPUS:66149160365
SN - 1066-5099
VL - 27
SP - 1205
EP - 1211
JO - Stem Cells
JF - Stem Cells
IS - 5
ER -