TY - JOUR
T1 - Stem cells in the heart
T2 - What's the buzz all about? Part 2: Arrhythmic risks and clinical studies
AU - Smith, Rachel Ruckdeschel
AU - Barile, Lucio
AU - Messina, Elisa
AU - Marbán, Eduardo
PY - 2008/6
Y1 - 2008/6
N2 - New approaches for cardiac repair have been enabled by the discovery that the heart contains its own reservoir of stem cells. In Part 1 of this review, we discussed various cardiac stem cell populations, reviewed our own work on cardiosphere-derived cells from human hearts, and outlined large animal preclinical models testing the regenerative potential of cardiac stem cells. Here we continue with a discussion on other adult stem cell sources with clinical potential. We summarize the critical safety issues associated with stem cell therapy and present the possible proarrhythmic and antiarrhythmic effects of stem cell transplantation. We discuss the outcomes of clinical stem cell trials and identify the technical, ethical, and practical issues facing the clinical application of cardiac stem cells.
AB - New approaches for cardiac repair have been enabled by the discovery that the heart contains its own reservoir of stem cells. In Part 1 of this review, we discussed various cardiac stem cell populations, reviewed our own work on cardiosphere-derived cells from human hearts, and outlined large animal preclinical models testing the regenerative potential of cardiac stem cells. Here we continue with a discussion on other adult stem cell sources with clinical potential. We summarize the critical safety issues associated with stem cell therapy and present the possible proarrhythmic and antiarrhythmic effects of stem cell transplantation. We discuss the outcomes of clinical stem cell trials and identify the technical, ethical, and practical issues facing the clinical application of cardiac stem cells.
KW - Arrhythmia
KW - Cardiac stem cells
KW - Myocardial infarction
KW - Myocardial regeneration
UR - http://www.scopus.com/inward/record.url?scp=46349110514&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=46349110514&partnerID=8YFLogxK
U2 - 10.1016/j.hrthm.2008.02.011
DO - 10.1016/j.hrthm.2008.02.011
M3 - Article
C2 - 18534373
AN - SCOPUS:46349110514
SN - 1547-5271
VL - 5
SP - 880
EP - 887
JO - Heart Rhythm
JF - Heart Rhythm
IS - 6
ER -