Stem cells in gynecology

Felicia L. Lane, Stephanie Jacobs

Research output: Contribution to journalReview article

Abstract

Stem cell based therapies hold promise for the obstetrician and gynecologist. This article reviews the history of stem cells and some of their current applications in gynecology. Currently, mesenchymal and muscle-derived stem cells are being explored for the treatment of urinary and anal incontinence. Potential stem cell treatments include fistula repair, vaginal tissue engineering, and graft material enhancement. Published animal and human pilot studies demonstrate improved histologic and functional outcomes in those receiving stem cells. Transplanted cells may improve function by local engraftment, trophic factors, or modulation of inflammation. Further clinical and safety studies are needed before clinical application.

Original languageEnglish (US)
Pages (from-to)149-156
Number of pages8
JournalAmerican journal of obstetrics and gynecology
Volume207
Issue number3
DOIs
StatePublished - Sep 1 2012
Externally publishedYes

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Keywords

  • gynecology
  • incontinence
  • mesenchymal
  • sphincter
  • stem cells

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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