Stem cells find their niche

Allan Spradling, Daniela Drummond-Barbosa, Toshie Kai

Research output: Contribution to journalReview article

Abstract

The concept that stem cells are controlled by particular microenvironments known as 'niches' has been widely invoked. But niches have remained largely a theoretical construct because of the difficulty of identifying and manipulating individual stem cells and their surroundings. Technical advances now make it possible to characterize small zones that maintain and control stem cell activity in several organs, including gonads, skin and gut. These studies are beginning to unify our understanding of stem cell regulation at the cellular and molecular levels, and promise to advance efforts to use stem cells therapeutically.

Original languageEnglish (US)
Pages (from-to)98-104
Number of pages7
JournalNature
Volume414
Issue number6859
DOIs
StatePublished - Nov 1 2001
Externally publishedYes

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ASJC Scopus subject areas

  • General

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