Stem cells find their niche

Allan Spradling; Daniela Drummond-Barbosa; Toshie Kai

doi:10.1038/35102160

Stem cells find their niche

Allan Spradling, Daniela Drummond-Barbosa, Toshie Kai

Research output: Contribution to journal › Review article › peer-review

1167 Scopus citations

Abstract

The concept that stem cells are controlled by particular microenvironments known as 'niches' has been widely invoked. But niches have remained largely a theoretical construct because of the difficulty of identifying and manipulating individual stem cells and their surroundings. Technical advances now make it possible to characterize small zones that maintain and control stem cell activity in several organs, including gonads, skin and gut. These studies are beginning to unify our understanding of stem cell regulation at the cellular and molecular levels, and promise to advance efforts to use stem cells therapeutically.

Original language	English (US)
Pages (from-to)	98-104
Number of pages	7
Journal	Nature
Volume	414
Issue number	6859
DOIs	https://doi.org/10.1038/35102160
State	Published - Nov 1 2001
Externally published	Yes

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10.1038/35102160

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AB - The concept that stem cells are controlled by particular microenvironments known as 'niches' has been widely invoked. But niches have remained largely a theoretical construct because of the difficulty of identifying and manipulating individual stem cells and their surroundings. Technical advances now make it possible to characterize small zones that maintain and control stem cell activity in several organs, including gonads, skin and gut. These studies are beginning to unify our understanding of stem cell regulation at the cellular and molecular levels, and promise to advance efforts to use stem cells therapeutically.

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Stem cells find their niche

Abstract

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