Stem Cells and Their Potential in Cell-Based Cardiac Therapies

Nicolas Christoforou, John D. Gearhart

Research output: Contribution to journalArticlepeer-review

Abstract

Stem cells are potential agents for the treatment of myocardial infarcts among other heart diseases. Over the past decade, the scientific community has extensively used a wide variety of cells and examined their capacity to both regenerate the infarcted myocardium and improve functionally the diseased hearts. Some of the cells used include skeletal myoblasts, bone marrow-derived cells, adult cardiac resident stem cells, mesenchymal stem cells, and both mouse and human embryonic stem cells (Nat Biotechnol 2005;23:845-856). The reported cardiogenic capacity of the utilitized stem cells is assayed both in vitro through the use of differentiation paradigms and in vivo through transplantation into a variety of animal models of cardiac disease. The purpose of this review article is to summarize recent stem cell applications in cell-based cardiac therapies and their outcomes.

Original languageEnglish (US)
Pages (from-to)396-413
Number of pages18
JournalProgress in Cardiovascular Diseases
Volume49
Issue number6
DOIs
StatePublished - May 2007

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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