Stem cell transplantation for spinal cord neurodegeneration

Angelo C. Lepore, Nicholas J. Maragakis

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Amyotrophic lateral sclerosis (ALS), a disorder that affects 30,000 individuals in the USA alone, is characterized by relatively rapid degeneration of upper and lower motor neurons, with death normally occurring 2-5 years following diagnosis due to respiratory paralysis. Transplantation of various classes of neural precursor cells (NPCs) is a promising therapeutic strategy for the treatment of traumatic CNS injury and neurodegeneration, including ALS, because of the ability to replace lost or dysfunctional CNS cell types, provide neuroprotection, and deliver gene factors of interest. In order to target cellular therapy to diaphragmatic dysfunction in models of ALS, NPCs can be transplanted specifically into the cervical spinal cord ventral gray matter of both SOD1 G93A rats and mice. The SOD1 G93A rats and mice are currently the most well-studied animal model of the disease.

Original languageEnglish (US)
Title of host publicationNeurodegeneration
Subtitle of host publicationMethods and Protocols
EditorsGiovanni Manfredi, Hibiki Kawamata
Pages479-493
Number of pages15
DOIs
StatePublished - 2011

Publication series

NameMethods in Molecular Biology
Volume793
ISSN (Print)1064-3745

Keywords

  • Amyotrophic lateral sclerosis
  • Cell transplantation
  • Degeneration
  • Engraftment
  • Graft
  • Motor neuron
  • Precursors
  • Spinal cord
  • Stem cells

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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