Stem cell transplantation for sickle cell disease: Can we reduce the toxicity?

J. Fixler, E. Vichinsky, M. C. Walters

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Since the genetic basis of sickle cell anemia was discovered over 50 years ago, many therapies have been developed for the treatment of this disorder. Hematopoietic cell transplantation offers curative potential, but it is associated with a 5-10% risk of dying. Patients who undergo allografting but develop stable donor-host hematopoietic chimerism appear to experience a significant clinical benefit. Our paper discusses the risks and benefits of hematopoietic cell transplantation in patients with sickle cell disease and summarizes the outcome of 147 patients who received allografts for sickle cell disease. We also review the development of new approaches to establish stable mixed chimerism after transplantation for sickle cell disease.

Original languageEnglish (US)
Pages (from-to)73-86
Number of pages14
JournalPediatric Pathology and Molecular Medicine
Issue number1
StatePublished - 2001
Externally publishedYes


  • Anemia
  • Bone marrow transplantation
  • Nonmyeloblative stem cell transplantation
  • Sickle cell
  • Transplantation chimera

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Pediatrics, Perinatology, and Child Health


Dive into the research topics of 'Stem cell transplantation for sickle cell disease: Can we reduce the toxicity?'. Together they form a unique fingerprint.

Cite this