Abstract
Stem cells of various origins, particularly endothelial progenitor cells (EPCs), have potential to enhance bone repair and regeneration. EPCs are resident in the bone marrow and home to ischemic sites to initiate vasculogenesis. Although it was previously believed that only local endothelial cells arrive at ischemic sites, new evidence suggests that EPCs are recruited from the periphery. This finding has a considerable array of therapeutic implications. For example, administered EPCs can localize to sites of osteogenesis where they increase blood vessel formation; this may be useful in enhancing fracture repair.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 62-72 |
| Number of pages | 11 |
| Journal | Annals of the New York Academy of Sciences |
| Volume | 1117 |
| DOIs | |
| State | Published - Jan 1 2007 |
| Externally published | Yes |
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Keywords
- Bone
- Endothelial progenitor cells
- Fracture repair
- Mesenchymal stem cells
- Stem cells
ASJC Scopus subject areas
- Neuroscience(all)
- Biochemistry, Genetics and Molecular Biology(all)
- History and Philosophy of Science
Cite this
Stem cell therapy in bone repair and regeneration. / Zaidi, Neeha; Nixon, Alan J.
In: Annals of the New York Academy of Sciences, Vol. 1117, 01.01.2007, p. 62-72.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Stem cell therapy in bone repair and regeneration
AU - Zaidi, Neeha
AU - Nixon, Alan J.
PY - 2007/1/1
Y1 - 2007/1/1
N2 - Stem cells of various origins, particularly endothelial progenitor cells (EPCs), have potential to enhance bone repair and regeneration. EPCs are resident in the bone marrow and home to ischemic sites to initiate vasculogenesis. Although it was previously believed that only local endothelial cells arrive at ischemic sites, new evidence suggests that EPCs are recruited from the periphery. This finding has a considerable array of therapeutic implications. For example, administered EPCs can localize to sites of osteogenesis where they increase blood vessel formation; this may be useful in enhancing fracture repair.
AB - Stem cells of various origins, particularly endothelial progenitor cells (EPCs), have potential to enhance bone repair and regeneration. EPCs are resident in the bone marrow and home to ischemic sites to initiate vasculogenesis. Although it was previously believed that only local endothelial cells arrive at ischemic sites, new evidence suggests that EPCs are recruited from the periphery. This finding has a considerable array of therapeutic implications. For example, administered EPCs can localize to sites of osteogenesis where they increase blood vessel formation; this may be useful in enhancing fracture repair.
KW - Bone
KW - Endothelial progenitor cells
KW - Fracture repair
KW - Mesenchymal stem cells
KW - Stem cells
UR - http://www.scopus.com/inward/record.url?scp=36549014651&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=36549014651&partnerID=8YFLogxK
U2 - 10.1196/annals.1402.074
DO - 10.1196/annals.1402.074
M3 - Article
C2 - 18056038
AN - SCOPUS:36549014651
VL - 1117
SP - 62
EP - 72
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
SN - 0077-8923
ER -